Effect of a coplanar PCB on lipid metabolism: the remarkable difference between rats and guinea pigs

M. Hatsumura, T. Ishida, Y. Ishii, N. Ariyoshi, K. Oguri, H. Yoshimura

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We studied the effect of 3, 4, 5, 3', 4'-pentachlorobiphenyl (PenCB) on lipid metabolism by determining the level of triacylglycerol and total cholesterol in rats and guinea pigs. Male Wistar rats and male Hartley guinea pigs received PenCB in corn oil one at a dose of 25 mg/kg i.p. and 0.5 mg/kg i.p., respectively. Pair-fed control group of both species were treated with the vehicle and given the amount of chow matched with that taken by the PenCB-treated animals. Free-fed control group was treated with vehicle and was given the chow ad libitum. The plasma was collected on the day 5 after the treatment and the liver was removed. The plasma triacylglycerol level in guinea pigs treated with PenCB was significantly higher than those in free- and pair-fed controls, whereas no significant difference was observed in PenCB-treated rats from both control groups. The plasma cholesterol level was also higher in PenCB-treated guinea pigs than in the two control groups, though the level in rats was significantly lower than the corresponding control values. The hepatic triacylglycerol and cholesterol levels were increased significantly in both species by the PenCB treatment. Although lipid metabolism was disordered in both animals by treatment with PenCB, the responsiveness was remarkably different between guinea pigs and rats. These differences could be associated with species difference in susceptibility toward toxic chlorinated aromatic hydrocarbons.

Original languageEnglish
Pages (from-to)135-143
Number of pages9
JournalFukuoka igaku zasshi = Hukuoka acta medica
Issue number5
Publication statusPublished - May 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Effect of a coplanar PCB on lipid metabolism: the remarkable difference between rats and guinea pigs'. Together they form a unique fingerprint.

Cite this