TY - JOUR
T1 - Effect of a low dose of midazolam on high blood pressure in dental patients
T2 - A randomised, double-blind, placebo-controlled, two-centre study
AU - Watanabe, Yoshihisa
AU - Higuchi, Hitoshi
AU - Maruhama, Minako
AU - Honda, Yuka
AU - Kawase, Akiko
AU - Yamane-Hirano, Ayaka
AU - Tomoyasu, Yumiko
AU - Maeda, Shigeru
AU - Miyawaki, Takuya
N1 - Publisher Copyright:
© 2016 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Some patients have transient hypertension before dental treatment as a result of anxiety and stress. Midazolam is an anxiolytic, and thought to be effective for the management of this sort of transient hypertension. We have evaluated in a randomised, controlled trial whether a low dose of midazolam can lower blood pressure in dental patients to an acceptable level without excessive sedation. Suitable patients were randomised to be given midazolam (trial group) or physiological saline (control group) intravenously. Blood pressure, heart rate, degree of anxiety, and amount of sedation were measured before and after injection. After injection, blood pressure in the trial group significantly decreased to clinically acceptable levels compared with controls. The degree of anxiety in the trial group was also significantly less than that in the control group, but there were no significant differences in sedation. These results suggest that injection of a low dose of midazolam stabilises the blood pressure of dental patients with transient hypertension.
AB - Some patients have transient hypertension before dental treatment as a result of anxiety and stress. Midazolam is an anxiolytic, and thought to be effective for the management of this sort of transient hypertension. We have evaluated in a randomised, controlled trial whether a low dose of midazolam can lower blood pressure in dental patients to an acceptable level without excessive sedation. Suitable patients were randomised to be given midazolam (trial group) or physiological saline (control group) intravenously. Blood pressure, heart rate, degree of anxiety, and amount of sedation were measured before and after injection. After injection, blood pressure in the trial group significantly decreased to clinically acceptable levels compared with controls. The degree of anxiety in the trial group was also significantly less than that in the control group, but there were no significant differences in sedation. These results suggest that injection of a low dose of midazolam stabilises the blood pressure of dental patients with transient hypertension.
KW - Anxiety
KW - Hypertension
KW - Midazolam
KW - Sedation
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U2 - 10.1016/j.bjoms.2016.02.006
DO - 10.1016/j.bjoms.2016.02.006
M3 - Article
C2 - 27006286
AN - SCOPUS:84962601294
SN - 0266-4356
VL - 54
SP - 443
EP - 448
JO - British Journal of Oral and Maxillofacial Surgery
JF - British Journal of Oral and Maxillofacial Surgery
IS - 4
ER -