Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion

Hiroyuki Ichikawa, Tomoichiro Yamaai, Zeqian Mo, Mengqing Xiang, Tomosada Sugimoto

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neurons were of various sizes in wildtype and heterozygous mice. In the knockout mice, however, most of CGRP-IR neurons were small. In the spinal cord of knockout mice, the number of CGRP-IR fibers increased in the dorsal column but decreased in the deep part of the dorsal horn. The loss of Brn-3a may have different effects on CGRP-IR expression in small and large DRG neurons.

Original languageEnglish
Pages (from-to)409-412
Number of pages4
Issue number4
Publication statusPublished - Mar 25 2002


  • Brn-3a
  • Calcitonin gene-related peptide
  • Dorsal root ganglion
  • Immunohistochemistry
  • Knockout mouse

ASJC Scopus subject areas

  • Neuroscience(all)


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