Effect of ceruletide on epileptogenesis in amygdaloid kindled rats

Yoshitaka Yamamoto; Toshifumi Itano; Osamu Miyamoto; Masaaki Tokuda; Hideki Matsui; Najma A. Janjua; Hiroshi Suwaki; Yasushi Okada; Tetsuro Negi; Tetuhide H. Murakami; Osamu Hatase

doi:10.1016/0006-8993(93)90678-G

Effect of ceruletide on epileptogenesis in amygdaloid kindled rats

Yoshitaka Yamamoto, Toshifumi Itano, Osamu Miyamoto, Masaaki Tokuda, Hideki Matsui, Najma A. Janjua, Hiroshi Suwaki, Yasushi Okada, Tetsuro Negi, Tetuhide H. Murakami, Osamu Hatase

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like, peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20-80 μg/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 μg.kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.

Original language	English
Pages (from-to)	353-356
Number of pages	4
Journal	Brain Research
Volume	630
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(93)90678-G
Publication status	Published - Dec 10 1993

Keywords

CCK
Ceruletide
Epilepsy
Kindling

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)90678-G

Cite this

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title = "Effect of ceruletide on epileptogenesis in amygdaloid kindled rats",

abstract = "The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like, peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20-80 μg/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 μg.kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.",

keywords = "CCK, Ceruletide, Epilepsy, Kindling",

author = "Yoshitaka Yamamoto and Toshifumi Itano and Osamu Miyamoto and Masaaki Tokuda and Hideki Matsui and Janjua, {Najma A.} and Hiroshi Suwaki and Yasushi Okada and Tetsuro Negi and Murakami, {Tetuhide H.} and Osamu Hatase",

note = "Funding Information: This work was supported by a Grant-in Aid for Scientific Research (C) from the Ministry of Education, Science and Culture of Japan.",

year = "1993",

month = dec,

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doi = "10.1016/0006-8993(93)90678-G",

language = "English",

volume = "630",

pages = "353--356",

journal = "Brain Research",

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TY - JOUR

T1 - Effect of ceruletide on epileptogenesis in amygdaloid kindled rats

AU - Yamamoto, Yoshitaka

AU - Itano, Toshifumi

AU - Miyamoto, Osamu

AU - Tokuda, Masaaki

AU - Matsui, Hideki

AU - Janjua, Najma A.

AU - Suwaki, Hiroshi

AU - Okada, Yasushi

AU - Negi, Tetsuro

AU - Murakami, Tetuhide H.

AU - Hatase, Osamu

N1 - Funding Information: This work was supported by a Grant-in Aid for Scientific Research (C) from the Ministry of Education, Science and Culture of Japan.

PY - 1993/12/10

Y1 - 1993/12/10

N2 - The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like, peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20-80 μg/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 μg.kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.

AB - The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like, peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20-80 μg/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 μg.kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.

KW - CCK

KW - Ceruletide

KW - Epilepsy

KW - Kindling

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DO - 10.1016/0006-8993(93)90678-G

M3 - Article

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AN - SCOPUS:0027386167

SN - 0006-8993

VL - 630

SP - 353

EP - 356

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Effect of ceruletide on epileptogenesis in amygdaloid kindled rats

Abstract

Keywords

ASJC Scopus subject areas

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