Effect of copper (II) ion against elongation behavior of amyloid β fibrils on liposome membranes

T. Shimanouchi; R. Onishi; N. Kitaura; H. Umakoshi; R. Kuboi

doi:10.1002/crat.201100344

Effect of copper (II) ion against elongation behavior of amyloid β fibrils on liposome membranes

T. Shimanouchi, R. Onishi, N. Kitaura, H. Umakoshi, R. Kuboi

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The fibril growth behavior of amyloid β protein (Aβ) on cell membranes is relating to the progression of Alzheimer's disease. This growth behavior of Aβ fibrils is sensitively affected by the metal ions, neurotransmitters, or bioreactive substrate. The inhibitory effect of those materials was quantitatively estimated from the viewpoints of "crystal growth". In a bulk aqueous solution, copper (II) ion showed the strong inhibitory effect on the growth of Aβ fibrils. Meanwhile, the addition of a closed-phospholipid bilayer membrane (liposome) could reduce the above inhibitory effect of copper (II) ion.

Original language	English
Pages (from-to)	101-108
Number of pages	8
Journal	Crystal Research and Technology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1002/crat.201100344
Publication status	Published - Jan 1 2012
Externally published	Yes

Keywords

amyloid fibrils
copper ions
inhibitory
liposome

ASJC Scopus subject areas

Chemistry(all)
Materials Science(all)
Condensed Matter Physics

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10.1002/crat.201100344

Cite this

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AU - Shimanouchi, T.

AU - Onishi, R.

AU - Kitaura, N.

AU - Umakoshi, H.

AU - Kuboi, R.

PY - 2012/1/1

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N2 - The fibril growth behavior of amyloid β protein (Aβ) on cell membranes is relating to the progression of Alzheimer's disease. This growth behavior of Aβ fibrils is sensitively affected by the metal ions, neurotransmitters, or bioreactive substrate. The inhibitory effect of those materials was quantitatively estimated from the viewpoints of "crystal growth". In a bulk aqueous solution, copper (II) ion showed the strong inhibitory effect on the growth of Aβ fibrils. Meanwhile, the addition of a closed-phospholipid bilayer membrane (liposome) could reduce the above inhibitory effect of copper (II) ion.

AB - The fibril growth behavior of amyloid β protein (Aβ) on cell membranes is relating to the progression of Alzheimer's disease. This growth behavior of Aβ fibrils is sensitively affected by the metal ions, neurotransmitters, or bioreactive substrate. The inhibitory effect of those materials was quantitatively estimated from the viewpoints of "crystal growth". In a bulk aqueous solution, copper (II) ion showed the strong inhibitory effect on the growth of Aβ fibrils. Meanwhile, the addition of a closed-phospholipid bilayer membrane (liposome) could reduce the above inhibitory effect of copper (II) ion.

KW - amyloid fibrils

KW - copper ions

KW - inhibitory

KW - liposome

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Effect of copper (II) ion against elongation behavior of amyloid β fibrils on liposome membranes

Abstract

Keywords

ASJC Scopus subject areas

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