Effect of dietary magnesium supplementation on intralymphocytic free calcium and magnesium in stroke-prone spontaneously hypertensive rats

Minoru Adachi; Yasuo Nara; Masayuki Mano; Yukio Yamori

doi:10.3109/10641969409072219

Effect of dietary magnesium supplementation on intralymphocytic free calcium and magnesium in stroke-prone spontaneously hypertensive rats

Minoru Adachi, Yasuo Nara, Masayuki Mano, Yukio Yamori

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The effects of dietary magnesium (Mg) supplementation on intralymphocytic free Ca²⁺ ([Ca²⁺]i) and Mg²⁺ ([Mg²⁺]i) were examined in the stroke-prone spontaneously hypertensive rats (SHRSP) at the age of 10 weeks. After 40 day Mg supplementation (0.8% Mg in the diet), systolic blood pressure (SBP) was significantly lower in Mg supplemented group (Mg group) than the control group (0.2% Mg). [Ca²⁺]i was significantly lower and [Mg²⁺]i was significantly higher in Mg group than in the control group. Further, [Ca²⁺]i was positively and [Mg²⁺]i was negatively correlated with SBP. These results suggest that dietary Mg supplementation modifies [Ca²⁺]i and [Mg²⁺]i, and modulates the development of hypertension.

Original language	English
Pages (from-to)	317-326
Number of pages	10
Journal	Clinical and Experimental Hypertension
Volume	16
Issue number	3
DOIs	https://doi.org/10.3109/10641969409072219
Publication status	Published - 1994
Externally published	Yes

Keywords

Dietary magnesium
Intralymphocytic free calcium
Intralymphocytic free magnesium
Stroke-prone spontaneously hypertensive rats

ASJC Scopus subject areas

Internal Medicine
Physiology

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10.3109/10641969409072219

Cite this

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title = "Effect of dietary magnesium supplementation on intralymphocytic free calcium and magnesium in stroke-prone spontaneously hypertensive rats",

abstract = "The effects of dietary magnesium (Mg) supplementation on intralymphocytic free Ca2+ ([Ca2+]i) and Mg2+ ([Mg2+]i) were examined in the stroke-prone spontaneously hypertensive rats (SHRSP) at the age of 10 weeks. After 40 day Mg supplementation (0.8% Mg in the diet), systolic blood pressure (SBP) was significantly lower in Mg supplemented group (Mg group) than the control group (0.2% Mg). [Ca2+]i was significantly lower and [Mg2+]i was significantly higher in Mg group than in the control group. Further, [Ca2+]i was positively and [Mg2+]i was negatively correlated with SBP. These results suggest that dietary Mg supplementation modifies [Ca2+]i and [Mg2+]i, and modulates the development of hypertension.",

keywords = "Dietary magnesium, Intralymphocytic free calcium, Intralymphocytic free magnesium, Stroke-prone spontaneously hypertensive rats",

author = "Minoru Adachi and Yasuo Nara and Masayuki Mano and Yukio Yamori",

year = "1994",

doi = "10.3109/10641969409072219",

language = "English",

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journal = "Clinical and Experimental Hypertension",

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TY - JOUR

T1 - Effect of dietary magnesium supplementation on intralymphocytic free calcium and magnesium in stroke-prone spontaneously hypertensive rats

AU - Adachi, Minoru

AU - Nara, Yasuo

AU - Mano, Masayuki

AU - Yamori, Yukio

PY - 1994

Y1 - 1994

N2 - The effects of dietary magnesium (Mg) supplementation on intralymphocytic free Ca2+ ([Ca2+]i) and Mg2+ ([Mg2+]i) were examined in the stroke-prone spontaneously hypertensive rats (SHRSP) at the age of 10 weeks. After 40 day Mg supplementation (0.8% Mg in the diet), systolic blood pressure (SBP) was significantly lower in Mg supplemented group (Mg group) than the control group (0.2% Mg). [Ca2+]i was significantly lower and [Mg2+]i was significantly higher in Mg group than in the control group. Further, [Ca2+]i was positively and [Mg2+]i was negatively correlated with SBP. These results suggest that dietary Mg supplementation modifies [Ca2+]i and [Mg2+]i, and modulates the development of hypertension.

AB - The effects of dietary magnesium (Mg) supplementation on intralymphocytic free Ca2+ ([Ca2+]i) and Mg2+ ([Mg2+]i) were examined in the stroke-prone spontaneously hypertensive rats (SHRSP) at the age of 10 weeks. After 40 day Mg supplementation (0.8% Mg in the diet), systolic blood pressure (SBP) was significantly lower in Mg supplemented group (Mg group) than the control group (0.2% Mg). [Ca2+]i was significantly lower and [Mg2+]i was significantly higher in Mg group than in the control group. Further, [Ca2+]i was positively and [Mg2+]i was negatively correlated with SBP. These results suggest that dietary Mg supplementation modifies [Ca2+]i and [Mg2+]i, and modulates the development of hypertension.

KW - Dietary magnesium

KW - Intralymphocytic free calcium

KW - Intralymphocytic free magnesium

KW - Stroke-prone spontaneously hypertensive rats

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ER -

Effect of dietary magnesium supplementation on intralymphocytic free calcium and magnesium in stroke-prone spontaneously hypertensive rats

Abstract

Keywords

ASJC Scopus subject areas

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