Effect of disordered structure of Boron-containing calcium phosphates on their in vitro biodegradability

Sabrina Barheine, Satoshi Hayakawa, Christian Jäger, Yuki Shirosaki, Akiyoshi Osaka

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


This study proposes a new guideline for designing biodegradable apatite ceramics. Boron-containing hydroxyapatite (BHAp) particles were prepared by a high-temperature solid-state reaction processing method and were characterized in terms of their chemical composition, apatite lattice defects and in vitro biodegradability. Solid-state nuclear magnetic resonance analysis showed that boron-incorporation into hydroxyapatite (HAp) derived by thermo-chemical reactions between borate and calcium phosphate phases led to disordered phases (BCaP) of a CaO-P2O5-B2O3-OH system covering the crystalline HAp core. X-ray diffraction analysis indicated that the BCaP phase must consist mainly of a crystalline oxyboroapatite (OBAp) phase. An in vitro biodegradability test showed that BHAp degraded quicker than HAp or β-tricalcium phosphate. The biodegradability of BHAp particles can be controlled by boron incorporation into a HAp lattice leading to the formation of a disordered OBAp phase.

Original languageEnglish
Pages (from-to)2656-2662
Number of pages7
JournalJournal of the American Ceramic Society
Issue number8
Publication statusPublished - Aug 2011

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry


Dive into the research topics of 'Effect of disordered structure of Boron-containing calcium phosphates on their in vitro biodegradability'. Together they form a unique fingerprint.

Cite this