Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells

Shunji Hayashi; Toshiro Sugiyama; Akira Yachi; Kenji Yokota; Yoshikazu Hirai; Keiji Oguma; Nobuhiro Fujii

doi:10.1007/BF02934107

Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells

Shunji Hayashi, Toshiro Sugiyama, Akira Yachi, Kenji Yokota, Yoshikazu Hirai, Keiji Oguma, Nobuhiro Fujii

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. pylori adhesion to gastric epithelial cells, using our previously established enzyme-linked immunosorbent assay. The adhesion of H. pylori was significantly inhibited by ecabet sodium in a dose-dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. pylori to gastric epithelial cells.

Original language	English
Pages (from-to)	593-597
Number of pages	5
Journal	Journal of Gastroenterology
Volume	32
Issue number	5
DOIs	https://doi.org/10.1007/BF02934107
Publication status	Published - Oct 1997

Keywords

Adhesion
Ecabet sodium
Gastric epithelial cells
Helicobacter pylori

ASJC Scopus subject areas

Gastroenterology

Access to Document

10.1007/BF02934107

Cite this

@article{968e680b0ad7466586bfe7806ea389cf,

title = "Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells",

abstract = "Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. pylori adhesion to gastric epithelial cells, using our previously established enzyme-linked immunosorbent assay. The adhesion of H. pylori was significantly inhibited by ecabet sodium in a dose-dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. pylori to gastric epithelial cells.",

keywords = "Adhesion, Ecabet sodium, Gastric epithelial cells, Helicobacter pylori",

author = "Shunji Hayashi and Toshiro Sugiyama and Akira Yachi and Kenji Yokota and Yoshikazu Hirai and Keiji Oguma and Nobuhiro Fujii",

year = "1997",

month = oct,

doi = "10.1007/BF02934107",

language = "English",

volume = "32",

pages = "593--597",

journal = "Journal of Gastroenterology",

issn = "0944-1174",

publisher = "Springer Japan",

number = "5",

}

TY - JOUR

T1 - Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells

AU - Hayashi, Shunji

AU - Sugiyama, Toshiro

AU - Yachi, Akira

AU - Yokota, Kenji

AU - Hirai, Yoshikazu

AU - Oguma, Keiji

AU - Fujii, Nobuhiro

PY - 1997/10

Y1 - 1997/10

N2 - Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. pylori adhesion to gastric epithelial cells, using our previously established enzyme-linked immunosorbent assay. The adhesion of H. pylori was significantly inhibited by ecabet sodium in a dose-dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. pylori to gastric epithelial cells.

AB - Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. pylori adhesion to gastric epithelial cells, using our previously established enzyme-linked immunosorbent assay. The adhesion of H. pylori was significantly inhibited by ecabet sodium in a dose-dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. pylori to gastric epithelial cells.

KW - Adhesion

KW - Ecabet sodium

KW - Gastric epithelial cells

KW - Helicobacter pylori

UR - http://www.scopus.com/inward/record.url?scp=0030668303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030668303&partnerID=8YFLogxK

U2 - 10.1007/BF02934107

DO - 10.1007/BF02934107

M3 - Article

C2 - 9349983

AN - SCOPUS:0030668303

SN - 0944-1174

VL - 32

SP - 593

EP - 597

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

IS - 5

ER -

Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this