Effect of epinastine hydrochloride (Alesion®) on the central nervous system

Chiaki Kamei, Miyuki Nishiga, Yuki Shigemoto, Masako Konishi, Kazuaki Shinomiya

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50 mg/kg, p.o. In contrast, olopatadine at 50 mg/kg and ketotifen at 10 mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50 mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20 mg/kg and 10 mg/kg, respectively.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalJapanese Pharmacology and Therapeutics
Issue number2
Publication statusPublished - Jan 1 2002


  • Active avoidance response
  • H-antagonists
  • Learning and memory
  • Second generation

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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