Effect of formaldehyde gas exposure in a murine allergic contact hypersensitivity model

Kazuyasu Fujii, Kazuhide Tsuji, Hironori Matsuura, Fusako Okazaki, Sachiko Takahashi, Jirô Arata, Keiji Iwatsuki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


To clarify the effect of formaldehyde (FA) gas exposure on contact hypersensitivity (CHS), CHS reactions against 2,4,6-trinitrochlorobenzene (TNCB) was studied in BALB/c mice with a low dose of FA gas exposure. The TNCB-induced CHS reactions were slightly suppressed by the FA gas exposure immediately after sensitization, whereas they were significantly enhanced and prolonged in mice continuously exposed to FA gas before and after sensitization. We showed that exposure to FA gas enhanced the Th2 dominant responses in draining lymph node (LN) in early stage of CHS. In contrast, T cell subsets and their intracellular cytokine production in the draining LN were similar during the early stage of CHS by FA gas exposure during the sensitization phase. The percentage of CD8+ T cells was increased, and the percentage of CD4 +CD25+ T cells was decreased in the FA gas-exposed group at 72 hr after elicitation. These results indicate that FA gas-exposed might influence regulatory T cells. Furthermore, in the chronic CHS model that was repetitively elicited with TNCB, more intensive and prolonged CHS reactions, and increased numbers of mast cells were found in the FA gas-exposed group at 4 hr after elicitation than in the control group, FA gas exposure may alter the intensity of allergic CHS.

Original languageEnglish
Pages (from-to)163-175
Number of pages13
JournalImmunopharmacology and Immunotoxicology
Issue number1
Publication statusPublished - 2005
Externally publishedYes


  • Contact hypersensitivity
  • Formaldehyde gas exposure
  • Sick-building syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology


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