TY - JOUR
T1 - Effect of glutamate receptor antagonists microinjected into the nucleus accumbens on place aversion induced by naloxone in single-dose, morphine-treated rats
AU - Kawasaki, Yoichi
AU - Ishida, Shigeru
AU - Jin, Chunyu
AU - Kitamura, Yoshihisa
AU - Kawasaki, Hiromu
AU - Gomita, Yutaka
AU - Sendo, Toshiaki
AU - Araki, Hiroaki
N1 - Funding Information:
This work was supported in part by a Grant-in Aid for Drug Abuse Research from the Ministry of Health and Welfare, Japan , and the Uehara Memorial Foundation .
PY - 2011/9
Y1 - 2011/9
N2 - It is well established that acute morphine withdrawal can be observed following opioid receptor antagonism in rodents. Glutamate receptor antagonists can attenuate the conditioning place aversion (CPA) induced by naloxone in single-dose, morphine-treated rats. Anatomically, the nucleus accumbens appears to be involved in opiate dependence. In the present study, we examined the effects of various glutamate receptor antagonists in the nucleus accumbens on naloxone-induced CPA in rats. MK-801 (an NMDA receptor antagonist), GYKI52466 (an AMPA receptor antagonist), and MCPG (a metabotropic glutamate receptor antagonist) significantly attenuated naloxone-induced CPA following microinjection into the accumbens. In contrast, none of the agents showed place conditioning ability on their own in either morphine-exposed or naïve rats. The present study suggests that glutamate receptors in the nucleus accumbens play a key role in the motivational component of withdrawal during acute morphine dependence.
AB - It is well established that acute morphine withdrawal can be observed following opioid receptor antagonism in rodents. Glutamate receptor antagonists can attenuate the conditioning place aversion (CPA) induced by naloxone in single-dose, morphine-treated rats. Anatomically, the nucleus accumbens appears to be involved in opiate dependence. In the present study, we examined the effects of various glutamate receptor antagonists in the nucleus accumbens on naloxone-induced CPA in rats. MK-801 (an NMDA receptor antagonist), GYKI52466 (an AMPA receptor antagonist), and MCPG (a metabotropic glutamate receptor antagonist) significantly attenuated naloxone-induced CPA following microinjection into the accumbens. In contrast, none of the agents showed place conditioning ability on their own in either morphine-exposed or naïve rats. The present study suggests that glutamate receptors in the nucleus accumbens play a key role in the motivational component of withdrawal during acute morphine dependence.
KW - Acute dependence
KW - Glutamine receptor antagonists
KW - Morphine
KW - Naloxone
KW - Nucleus accumbens
KW - Place aversion
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U2 - 10.1016/j.ejphar.2011.05.022
DO - 10.1016/j.ejphar.2011.05.022
M3 - Article
C2 - 21635886
AN - SCOPUS:79960025369
SN - 0014-2999
VL - 666
SP - 131
EP - 134
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -