Abstract
The effect of glycyrrhizin on the amine dynamics in noradrenergic, dopaminergic or serotonergic nervous system in the rat brain was investigated. Following repeated subcutaneous administration of glycyrrhizin 50mg/kg for 7 days, significant decreases in the 4-hydroxy-3-methoxy- phenylglycol(MHPG)/norepinephrine(NE) ratio in the hippocampus and hypothalamus were produced. Glycyrrhizin 50 mg/kg s.c. also caused a significant decrease in 3,4-dihydroxyphenylacetic acid(DOPAC)/dopamine (DA) ratio in the hippocampus. But, Glycyrrhizin did not induced significant changes in 5-hydroxyindole-3 acetic acid (5-HIAA)/serotonin (5-HT) ratio in 4 regions of the brain. These findings suggest that hight doses of glycyrrhizin decreases NE or DA turnover in hippocampus and hypothalamus as a result of the interference with the NE or DA content in the neuron, but therapeutic doses of glycyrrhizin dose not cause a significant change on monoamine turnover in the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 171-175 |
| Number of pages | 5 |
| Journal | Japanese Pharmacology and Therapeutics |
| Volume | 27 |
| Issue number | 4 |
| Publication status | Published - 1999 |
| Externally published | Yes |
Keywords
- Glycyrrhizin
- Monoamine
- Rat brain
- Turnover
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)