TY - JOUR
T1 - Effect of Low Dose Cyclophosphamide on the Synthesis of Acute Phase Protein and Its Significance for Cancer Chemotherapy
AU - Iwagaki, Hiromi
AU - Hizuta, Akio
AU - Fujiwara, Toshiyoshi
AU - Perdomo, Jose Antonio
AU - Tanaka, Noriaki
AU - Orita, Kunzo
PY - 1996/10/1
Y1 - 1996/10/1
N2 - Patients with far advanced colorectal cancers received chemotherapy consisting of low-dose cyclophosphamide (LDCY) 333 mg/m2 every four weeks intravenously and by oral administration of 5'-DFUR (a masked compound of 5-Fluorouracil). Serum levels of immunosuppressive acidic protein (IAP), an acute phase protein, were measured every four weeks for a total of thirty-one LDCY trials of ten patients. LDCY chemotherapy significantly decreased the IAP levels in cancer patients with high IAP levels. These results suggested that LDCY chemotherapy could counteract host responses against tumors and could have decreased immunosuppressive responses in cancer patients.
AB - Patients with far advanced colorectal cancers received chemotherapy consisting of low-dose cyclophosphamide (LDCY) 333 mg/m2 every four weeks intravenously and by oral administration of 5'-DFUR (a masked compound of 5-Fluorouracil). Serum levels of immunosuppressive acidic protein (IAP), an acute phase protein, were measured every four weeks for a total of thirty-one LDCY trials of ten patients. LDCY chemotherapy significantly decreased the IAP levels in cancer patients with high IAP levels. These results suggested that LDCY chemotherapy could counteract host responses against tumors and could have decreased immunosuppressive responses in cancer patients.
KW - Acute phase protein
KW - Immunosuppressive acidic protein
KW - Low-dose cyclophosphamide
UR - http://www.scopus.com/inward/record.url?scp=0030254687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030254687&partnerID=8YFLogxK
M3 - Article
C2 - 8914681
AN - SCOPUS:0030254687
SN - 0386-300X
VL - 50
SP - 271
EP - 272
JO - Acta medica Okayama
JF - Acta medica Okayama
IS - 5
ER -
