Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats

Mikihiko Kogo; Atsuyuki Mori; Hidehiko Koizumi; Koji Ishihama; Seji Iida; Susumu Tanaka; Tokuzo Matsuya

doi:10.1016/S0361-9230(00)00322-1

Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats

Mikihiko Kogo, Atsuyuki Mori, Hidehiko Koizumi, Koji Ishihama, Seji Iida, Susumu Tanaka, Tokuzo Matsuya

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

N-methyl-D,L-aspartate acid and bicuculline are required to enhance the trigeminal rhythmic activities in an in vitro isolated brainstem block preparation. In this study, we analyzed the effect of norepinephrine on the trigeminal neural circuit underlying rhythmic jaw movements. Rhythmic trigeminal activity is observed in brainstem preparations (inferior colliculus to obex) only following blockade of α₂-adrenoceptors with idazoxan. This observation, combined with the inhibition of rhythm by α₂-adrenoceptor agonists suggests endogenous α₂-adrenoceptor mediated inhibition of trigeminal networks. A complex noradrenergic modulation of trigeminal systems is further supported by the prazosin-sensitive potentiation of rhythm by bath application of the α₁-adrenoceptor agonist phenylephrine. Copyright (C) 2000 Elsevier Science Inc.

Original language	English
Pages (from-to)	171-174
Number of pages	4
Journal	Brain Research Bulletin
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/S0361-9230(00)00322-1
Publication status	Published - Sept 15 2000
Externally published	Yes

Keywords

In vitro brainstem preparation
Mastication
Norepinephrine
Rhythm generation
Trigeminal motor activity

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0361-9230(00)00322-1

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title = "Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats",

abstract = "N-methyl-D,L-aspartate acid and bicuculline are required to enhance the trigeminal rhythmic activities in an in vitro isolated brainstem block preparation. In this study, we analyzed the effect of norepinephrine on the trigeminal neural circuit underlying rhythmic jaw movements. Rhythmic trigeminal activity is observed in brainstem preparations (inferior colliculus to obex) only following blockade of α2-adrenoceptors with idazoxan. This observation, combined with the inhibition of rhythm by α2-adrenoceptor agonists suggests endogenous α2-adrenoceptor mediated inhibition of trigeminal networks. A complex noradrenergic modulation of trigeminal systems is further supported by the prazosin-sensitive potentiation of rhythm by bath application of the α1-adrenoceptor agonist phenylephrine. Copyright (C) 2000 Elsevier Science Inc.",

keywords = "In vitro brainstem preparation, Mastication, Norepinephrine, Rhythm generation, Trigeminal motor activity",

author = "Mikihiko Kogo and Atsuyuki Mori and Hidehiko Koizumi and Koji Ishihama and Seji Iida and Susumu Tanaka and Tokuzo Matsuya",

note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research A-10307050 and B-09832006 from the Ministry of Education, Science and Culture of Japan.",

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doi = "10.1016/S0361-9230(00)00322-1",

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AU - Kogo, Mikihiko

AU - Mori, Atsuyuki

AU - Koizumi, Hidehiko

AU - Ishihama, Koji

AU - Iida, Seji

AU - Tanaka, Susumu

AU - Matsuya, Tokuzo

N1 - Funding Information: This work was supported by Grants-in-Aid for Scientific Research A-10307050 and B-09832006 from the Ministry of Education, Science and Culture of Japan.

PY - 2000/9/15

Y1 - 2000/9/15

N2 - N-methyl-D,L-aspartate acid and bicuculline are required to enhance the trigeminal rhythmic activities in an in vitro isolated brainstem block preparation. In this study, we analyzed the effect of norepinephrine on the trigeminal neural circuit underlying rhythmic jaw movements. Rhythmic trigeminal activity is observed in brainstem preparations (inferior colliculus to obex) only following blockade of α2-adrenoceptors with idazoxan. This observation, combined with the inhibition of rhythm by α2-adrenoceptor agonists suggests endogenous α2-adrenoceptor mediated inhibition of trigeminal networks. A complex noradrenergic modulation of trigeminal systems is further supported by the prazosin-sensitive potentiation of rhythm by bath application of the α1-adrenoceptor agonist phenylephrine. Copyright (C) 2000 Elsevier Science Inc.

AB - N-methyl-D,L-aspartate acid and bicuculline are required to enhance the trigeminal rhythmic activities in an in vitro isolated brainstem block preparation. In this study, we analyzed the effect of norepinephrine on the trigeminal neural circuit underlying rhythmic jaw movements. Rhythmic trigeminal activity is observed in brainstem preparations (inferior colliculus to obex) only following blockade of α2-adrenoceptors with idazoxan. This observation, combined with the inhibition of rhythm by α2-adrenoceptor agonists suggests endogenous α2-adrenoceptor mediated inhibition of trigeminal networks. A complex noradrenergic modulation of trigeminal systems is further supported by the prazosin-sensitive potentiation of rhythm by bath application of the α1-adrenoceptor agonist phenylephrine. Copyright (C) 2000 Elsevier Science Inc.

KW - In vitro brainstem preparation

KW - Mastication

KW - Norepinephrine

KW - Rhythm generation

KW - Trigeminal motor activity

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Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats

Abstract

Keywords

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