Effect of oxidative stress on cardiovascular system in response to gravity

Ken Takahashi, Hiroki Okumura, Rui Guo, Keiji Naruse

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


Long-term habitation in space leads to physiological alterations such as bone loss, muscle atrophy, and cardiovascular deconditioning. Two predominant factors—namely space radiation and microgravity—have a crucial impact on oxidative stress in living organisms. Oxidative stress is also involved in the aging process, and plays important roles in the development of cardiovascular diseases including hypertension, left ventricular hypertrophy, and myocardial infarction. Here, we discuss the effects of space radiation, microgravity, and a combination of these two factors on oxidative stress. Future research may facilitate safer living in space by reducing the adverse effects of oxidative stress.

Original languageEnglish
Article number1426
JournalInternational journal of molecular sciences
Issue number7
Publication statusPublished - Jul 4 2017


  • Microgravity
  • Oxidative stress
  • Radiation
  • Reactive oxygen species

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'Effect of oxidative stress on cardiovascular system in response to gravity'. Together they form a unique fingerprint.

Cite this