Effect of paroxetine on marble-burying behavior in mice

Kazuaki Shinomiya, Y. Fujii, Y. Sugimoto, N. Azuma, S. Tokunaga, K. Kitazumi, C. Kamei

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The present study was undertaken to investigate the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI), on marble-burying behavior in mice in comparison with those of fluvoxamine and clomipramine. Marble-burying test is extensively used as an animal model for obsessive/compulsive disorder. A significant inhibition in marble-burying behavior was observed with paroxetine, at a dose of 10 mg/kg. The earlier SSRI, fluvoxamine, also significantly inhibited marble-burying behavior at a dose of 30 mg/kg. Although clomipramine, a tricyclic antidepressant, caused an inhibition in marble-burying behavior, a high dose of 100 mg/kg was needed to show a significant effect. On the other hand, all the drugs used in the present study showed no significant changes in spontaneous locomotor activity at doses inhibiting marble-burying behavior. In conclusion, it was confirmed that paroxetine has a potent inhibitory effect on marble-burying behavior in mice, and could have a similar antiobsessive/ anticompulsive activity in human beings.

Original languageEnglish
Pages (from-to)685-687
Number of pages3
JournalMethods and Findings in Experimental and Clinical Pharmacology
Issue number10
Publication statusPublished - Dec 2005


  • Clomipramine
  • Fluvoxamine
  • Marble-burying behavior
  • Mice
  • Paroxetine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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