Effect of roxithromycin against biofilm formed by Staphylococcus aureus

Osamu Yamasaki, Hisanori Akiyama, Takashi Oono, Keiji Iwatsuki, Jirô Arata

Research output: Contribution to journalArticlepeer-review


We examined the effect of roxithromycin against biofilms formed by Staphylococcus aureus. No combined effect of roxithromycin and imipenem was observed in a biofilm model on coverslips. In a murine model for biofilm formation, however, the combination treatment significantly decreased the number of viable bacterial cells compared with the control. Histologically, neutrophils invaded the bacterial clusters in the roxithromycin treated groups. These findings suggest that roxithromycin can induce the invasion of neutrophils and enhance therapeutic efficacy of imipenem. Confocal laser microscopic observation on glycocalyx production by S. aureus revealed that sub-MIC roxithromycin inhibited glycocalyx production. The effects of roxithromycin on biofilm formation by S. aureus were the eradication of biofilm and the inhibition of biofilm formation. The results of this study indicate that roxithromycin are a potentially effective treatment for S. aureus biofilm associated skin infection.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalSkin Research
Issue numberSUPPL. 1
Publication statusPublished - Aug 2002
Externally publishedYes


  • Biofilm
  • Imipenem
  • Macrolide
  • Roxithromycin
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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