Effect of spatial design and thermal oxidation on apatite formation on Ti-15Zr-4Ta-4Nb alloy

Atsushi Sugino; Chikara Ohtsuki; Kanji Tsuru; Satoshi Hayakawa; Takayoshi Nakano; Yoshimitsu Okazaki; Akiyoshi Osaka

doi:10.1016/j.actbio.2008.07.014

Effect of spatial design and thermal oxidation on apatite formation on Ti-15Zr-4Ta-4Nb alloy

Atsushi Sugino, Chikara Ohtsuki, Kanji Tsuru, Satoshi Hayakawa, Takayoshi Nakano, Yoshimitsu Okazaki, Akiyoshi Osaka

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Apatite formation on the surface of titanium and its alloys is effective for inducing osteoconductivity when implanted in bony defects. The aim of this study was to investigate the effects of thermal oxidation on apatite formation in macro-grooves on Ti-15Zr-4Ta-4Nb. Thermal oxidation at 500 and 600 °C in air led to modification of the Ti-15Zr-4Ta-4Nb surface to rutile phase titanium oxide. Ti-15Zr-4Ta-4Nb thermally oxidized at 500 °C in air showed no changes in metallographic structure, but not at 600 °C. After soaking in a simulated body fluid for 7 days, the formation of apatite could be observed on the internal surfaces of macro-grooves 500 μm deep and wide on Ti-15Zr-4Ta-4Nb thermally oxidized at 500 and 600 °C in air. These results indicate the potential for osteoconductivity of Ti-15Zr-4Ta-4Nb without changing its metallographic structure, by fabricating only the macro-grooves, i.e., spatial design, and by performing thermal oxidation at 500 °C.

Original language	English
Pages (from-to)	298-304
Number of pages	7
Journal	Acta Biomaterialia
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.actbio.2008.07.014
Publication status	Published - Jan 2009

Keywords

Apatite
Bioactivity
Macro-grooves
Thermal oxidation
Titanium alloy

ASJC Scopus subject areas

Biotechnology
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Biology

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10.1016/j.actbio.2008.07.014

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title = "Effect of spatial design and thermal oxidation on apatite formation on Ti-15Zr-4Ta-4Nb alloy",

abstract = "Apatite formation on the surface of titanium and its alloys is effective for inducing osteoconductivity when implanted in bony defects. The aim of this study was to investigate the effects of thermal oxidation on apatite formation in macro-grooves on Ti-15Zr-4Ta-4Nb. Thermal oxidation at 500 and 600 °C in air led to modification of the Ti-15Zr-4Ta-4Nb surface to rutile phase titanium oxide. Ti-15Zr-4Ta-4Nb thermally oxidized at 500 °C in air showed no changes in metallographic structure, but not at 600 °C. After soaking in a simulated body fluid for 7 days, the formation of apatite could be observed on the internal surfaces of macro-grooves 500 μm deep and wide on Ti-15Zr-4Ta-4Nb thermally oxidized at 500 and 600 °C in air. These results indicate the potential for osteoconductivity of Ti-15Zr-4Ta-4Nb without changing its metallographic structure, by fabricating only the macro-grooves, i.e., spatial design, and by performing thermal oxidation at 500 °C.",

keywords = "Apatite, Bioactivity, Macro-grooves, Thermal oxidation, Titanium alloy",

author = "Atsushi Sugino and Chikara Ohtsuki and Kanji Tsuru and Satoshi Hayakawa and Takayoshi Nakano and Yoshimitsu Okazaki and Akiyoshi Osaka",

note = "Funding Information: This work was financially supported in part by Medical Techno Okayama and Chugoku Bureau of Economy, Trade, and Industry. The authors also thank Mr. T. Shozui and Ms. N. Iwamoto of Okayama University, Mr. T. Ishimoto and Ms. S. Miyabe of Osaka University for technical assistance in this study.",

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doi = "10.1016/j.actbio.2008.07.014",

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T1 - Effect of spatial design and thermal oxidation on apatite formation on Ti-15Zr-4Ta-4Nb alloy

AU - Sugino, Atsushi

AU - Ohtsuki, Chikara

AU - Tsuru, Kanji

AU - Hayakawa, Satoshi

AU - Nakano, Takayoshi

AU - Okazaki, Yoshimitsu

AU - Osaka, Akiyoshi

N1 - Funding Information: This work was financially supported in part by Medical Techno Okayama and Chugoku Bureau of Economy, Trade, and Industry. The authors also thank Mr. T. Shozui and Ms. N. Iwamoto of Okayama University, Mr. T. Ishimoto and Ms. S. Miyabe of Osaka University for technical assistance in this study.

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N2 - Apatite formation on the surface of titanium and its alloys is effective for inducing osteoconductivity when implanted in bony defects. The aim of this study was to investigate the effects of thermal oxidation on apatite formation in macro-grooves on Ti-15Zr-4Ta-4Nb. Thermal oxidation at 500 and 600 °C in air led to modification of the Ti-15Zr-4Ta-4Nb surface to rutile phase titanium oxide. Ti-15Zr-4Ta-4Nb thermally oxidized at 500 °C in air showed no changes in metallographic structure, but not at 600 °C. After soaking in a simulated body fluid for 7 days, the formation of apatite could be observed on the internal surfaces of macro-grooves 500 μm deep and wide on Ti-15Zr-4Ta-4Nb thermally oxidized at 500 and 600 °C in air. These results indicate the potential for osteoconductivity of Ti-15Zr-4Ta-4Nb without changing its metallographic structure, by fabricating only the macro-grooves, i.e., spatial design, and by performing thermal oxidation at 500 °C.

AB - Apatite formation on the surface of titanium and its alloys is effective for inducing osteoconductivity when implanted in bony defects. The aim of this study was to investigate the effects of thermal oxidation on apatite formation in macro-grooves on Ti-15Zr-4Ta-4Nb. Thermal oxidation at 500 and 600 °C in air led to modification of the Ti-15Zr-4Ta-4Nb surface to rutile phase titanium oxide. Ti-15Zr-4Ta-4Nb thermally oxidized at 500 °C in air showed no changes in metallographic structure, but not at 600 °C. After soaking in a simulated body fluid for 7 days, the formation of apatite could be observed on the internal surfaces of macro-grooves 500 μm deep and wide on Ti-15Zr-4Ta-4Nb thermally oxidized at 500 and 600 °C in air. These results indicate the potential for osteoconductivity of Ti-15Zr-4Ta-4Nb without changing its metallographic structure, by fabricating only the macro-grooves, i.e., spatial design, and by performing thermal oxidation at 500 °C.

KW - Apatite

KW - Bioactivity

KW - Macro-grooves

KW - Thermal oxidation

KW - Titanium alloy

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Effect of spatial design and thermal oxidation on apatite formation on Ti-15Zr-4Ta-4Nb alloy

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Keywords

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