Effects of a high-cholesterol diet on cell behavior in rat periodontitis

Takaaki Tomofuji, H. Kusano, Tetsuji Azuma, D. Ekuni, T. Yamamoto, T. Watanabe

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Studies have shown an association between periodontitis and serum cholesterol levels. We hypothesized that high dietary cholesterol could influence periodontitis as a result of proliferation of the junctional epithelium. Rats were divided into 4 groups. Two groups were fed a regular diet, and 2 groups were fed a high-cholesterol diet. One of each dietary group was treated with periodontitis-inducing agents (lipopolysaccharide and proteases), while the other was treated with pyrogen-free water. Feeding rats with a high-cholesterol diet induced an increase in blood total cholesterol and a decrease in high-density lipoprotein cholesterol. Proliferation of the junctional epithelium with increasing bone resorption was promoted by the consumption of a high-cholesterol diet. High dietary cholesterol further increased the cell-proliferative activity of the junctional epithelium induced by lipopolysaccharide and proteases. These results suggest that high dietary cholesterol can initiate and augment periodontitis in the rat periodontitis model.

Original languageEnglish
Pages (from-to)752-756
Number of pages5
Issue number1675
Publication statusPublished - Oct 2005


  • Apoptosis
  • Cell proliferation
  • Dietary cholesterol
  • Periodontitis
  • Serum lipids

ASJC Scopus subject areas

  • Family Practice


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