Effects of asbestos fibers on human cytotoxic T cells

Naoko Kumagai-Takei; Yasumitsu Nishimura; Hidenori Matsuzaki; Megumi Maeda; Suni Lee; Kei Yoshitome; Takemi Otsuki

doi:10.1007/978-4-431-55732-6_12

Effects of asbestos fibers on human cytotoxic T cells

Naoko Kumagai-Takei, Yasumitsu Nishimura, Hidenori Matsuzaki, Megumi Maeda, Suni Lee, Kei Yoshitome, Takemi Otsuki

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

Abstract

The immunological effects of asbestos have been demonstrated and include reduction of antitumor immunity such as the reduction of natural killer (NK) cell activity with decreased expression of NK cell-activating receptor, NKp46, as well as reduced expression of CXCR3, chemokine receptor, and interferon (IFN)-γ in CD4+ T cells. In this review, the effects of asbestos as demonstrated by our investigations on the cellular characteristics and functions of cytotoxic T lymphocytes (CTLs) differentiated from CD8+ T cells are shown and discussed. Experiments involving in vitro exposure of chrysotile asbestos onto a mixed lymphocyte reaction (MLR) assay to estimate clonal expansion (proliferation and differentiation) of CD8+ T cells revealed the inhibition of both proliferation and differentiation. These results should be interpreted as the impairment of CTL differentiation in the lymph nodes, where asbestos fibers are located continuously in asbestos-exposed people. In addition, analyses of cellular functions in asbestos-exposed patients with pleural plaque (PP) and malignant mesothelioma (MM) are discussed. PP patients showed an increase in effector memory CD8+ T cells compared to healthy donors or MM patients. Furthermore, MM patients showed a decrease in perforin-expressing CD8+ T cells. These results indicated that although asbestos-exposed individuals are ready to respond with transformed cells, CTLs may lose their function once mesothelioma progresses.

Original language	English
Title of host publication	Biological Effects of Fibrous and Particulate Substances
Publisher	Springer Japan
Pages	211-221
Number of pages	11
ISBN (Print)	9784431557326, 9784431557319
DOIs	https://doi.org/10.1007/978-4-431-55732-6_12
Publication status	Published - Oct 26 2015

Keywords

Asbestos
CTL (cytotoxic T cell)
Interferon γ
Malignant mesothelioma
Perforin
Pleural plaque

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Medicine(all)
Immunology and Microbiology(all)

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10.1007/978-4-431-55732-6_12

Cite this

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title = "Effects of asbestos fibers on human cytotoxic T cells",

abstract = "The immunological effects of asbestos have been demonstrated and include reduction of antitumor immunity such as the reduction of natural killer (NK) cell activity with decreased expression of NK cell-activating receptor, NKp46, as well as reduced expression of CXCR3, chemokine receptor, and interferon (IFN)-γ in CD4+ T cells. In this review, the effects of asbestos as demonstrated by our investigations on the cellular characteristics and functions of cytotoxic T lymphocytes (CTLs) differentiated from CD8+ T cells are shown and discussed. Experiments involving in vitro exposure of chrysotile asbestos onto a mixed lymphocyte reaction (MLR) assay to estimate clonal expansion (proliferation and differentiation) of CD8+ T cells revealed the inhibition of both proliferation and differentiation. These results should be interpreted as the impairment of CTL differentiation in the lymph nodes, where asbestos fibers are located continuously in asbestos-exposed people. In addition, analyses of cellular functions in asbestos-exposed patients with pleural plaque (PP) and malignant mesothelioma (MM) are discussed. PP patients showed an increase in effector memory CD8+ T cells compared to healthy donors or MM patients. Furthermore, MM patients showed a decrease in perforin-expressing CD8+ T cells. These results indicated that although asbestos-exposed individuals are ready to respond with transformed cells, CTLs may lose their function once mesothelioma progresses.",

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author = "Naoko Kumagai-Takei and Yasumitsu Nishimura and Hidenori Matsuzaki and Megumi Maeda and Suni Lee and Kei Yoshitome and Takemi Otsuki",

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AU - Kumagai-Takei, Naoko

AU - Nishimura, Yasumitsu

AU - Matsuzaki, Hidenori

AU - Maeda, Megumi

AU - Lee, Suni

AU - Yoshitome, Kei

AU - Otsuki, Takemi

PY - 2015/10/26

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AB - The immunological effects of asbestos have been demonstrated and include reduction of antitumor immunity such as the reduction of natural killer (NK) cell activity with decreased expression of NK cell-activating receptor, NKp46, as well as reduced expression of CXCR3, chemokine receptor, and interferon (IFN)-γ in CD4+ T cells. In this review, the effects of asbestos as demonstrated by our investigations on the cellular characteristics and functions of cytotoxic T lymphocytes (CTLs) differentiated from CD8+ T cells are shown and discussed. Experiments involving in vitro exposure of chrysotile asbestos onto a mixed lymphocyte reaction (MLR) assay to estimate clonal expansion (proliferation and differentiation) of CD8+ T cells revealed the inhibition of both proliferation and differentiation. These results should be interpreted as the impairment of CTL differentiation in the lymph nodes, where asbestos fibers are located continuously in asbestos-exposed people. In addition, analyses of cellular functions in asbestos-exposed patients with pleural plaque (PP) and malignant mesothelioma (MM) are discussed. PP patients showed an increase in effector memory CD8+ T cells compared to healthy donors or MM patients. Furthermore, MM patients showed a decrease in perforin-expressing CD8+ T cells. These results indicated that although asbestos-exposed individuals are ready to respond with transformed cells, CTLs may lose their function once mesothelioma progresses.

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ER -

Effects of asbestos fibers on human cytotoxic T cells

Abstract

Keywords

ASJC Scopus subject areas

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