Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice

Ryoko Ohnishi; Hideyuki Ito; Ayumu Iguchi; Kazuaki Shinomiya; Chiaki Kamei; Tsutomu Hatano; Takashi Yoshida

doi:10.1271/bbb.60243

Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice

Ryoko Ohnishi, Hideyuki Ito, Ayumu Iguchi, Kazuaki Shinomiya, Chiaki Kamei, Tsutomu Hatano, Takashi Yoshida

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Chlorogenic acid possessed a weak caffeine-like psychostimulant property when assessed for its effect on spontaneous locomotor activity in mice. In the evaluation of the effects for the major metabolites of chlorogenic acid which were detected upon incubation with rat feces and/or excreted in urine after oral administration to rats, caffeic and m-coumaric acids were found to be the principal active metabolites, while the others contributed little to this caffeine-like psychostimulant activity.

Original language	English
Pages (from-to)	2560-2563
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	70
Issue number	10
DOIs	https://doi.org/10.1271/bbb.60243
Publication status	Published - 2006

Keywords

Caffeic acid
Chlorogenic acid
Microbial metabolite
Psychostimulant activity
Spontaneous locomotor activity

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.60243

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title = "Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice",

abstract = "Chlorogenic acid possessed a weak caffeine-like psychostimulant property when assessed for its effect on spontaneous locomotor activity in mice. In the evaluation of the effects for the major metabolites of chlorogenic acid which were detected upon incubation with rat feces and/or excreted in urine after oral administration to rats, caffeic and m-coumaric acids were found to be the principal active metabolites, while the others contributed little to this caffeine-like psychostimulant activity.",

keywords = "Caffeic acid, Chlorogenic acid, Microbial metabolite, Psychostimulant activity, Spontaneous locomotor activity",

author = "Ryoko Ohnishi and Hideyuki Ito and Ayumu Iguchi and Kazuaki Shinomiya and Chiaki Kamei and Tsutomu Hatano and Takashi Yoshida",

note = "Funding Information: This study was supported in part by a Grant-in-Aid for Scientific Research (No. 17604005, to H.I.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors are grateful to the SC-NMR Laboratory of Okayama University for 1H NMR measurements.",

year = "2006",

doi = "10.1271/bbb.60243",

language = "English",

volume = "70",

pages = "2560--2563",

journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice

AU - Ohnishi, Ryoko

AU - Ito, Hideyuki

AU - Iguchi, Ayumu

AU - Shinomiya, Kazuaki

AU - Kamei, Chiaki

AU - Hatano, Tsutomu

AU - Yoshida, Takashi

N1 - Funding Information: This study was supported in part by a Grant-in-Aid for Scientific Research (No. 17604005, to H.I.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors are grateful to the SC-NMR Laboratory of Okayama University for 1H NMR measurements.

PY - 2006

Y1 - 2006

N2 - Chlorogenic acid possessed a weak caffeine-like psychostimulant property when assessed for its effect on spontaneous locomotor activity in mice. In the evaluation of the effects for the major metabolites of chlorogenic acid which were detected upon incubation with rat feces and/or excreted in urine after oral administration to rats, caffeic and m-coumaric acids were found to be the principal active metabolites, while the others contributed little to this caffeine-like psychostimulant activity.

AB - Chlorogenic acid possessed a weak caffeine-like psychostimulant property when assessed for its effect on spontaneous locomotor activity in mice. In the evaluation of the effects for the major metabolites of chlorogenic acid which were detected upon incubation with rat feces and/or excreted in urine after oral administration to rats, caffeic and m-coumaric acids were found to be the principal active metabolites, while the others contributed little to this caffeine-like psychostimulant activity.

KW - Caffeic acid

KW - Chlorogenic acid

KW - Microbial metabolite

KW - Psychostimulant activity

KW - Spontaneous locomotor activity

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SN - 0916-8451

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 10

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Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice

Abstract

Keywords

ASJC Scopus subject areas

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