Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats

Kozo Yamaji; Masamitsu Kawanami; Atsushi Matsumoto; Tomoomi Odajima; Yoshihiro Nishitani; Kensuke Iwasaka; Keiko Yoshimitsu; Masahiro Yoshiyama

doi:10.4012/dmj.26.481

Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats

Kozo Yamaji, Masamitsu Kawanami, Atsushi Matsumoto, Tomoomi Odajima, Yoshihiro Nishitani, Kensuke Iwasaka, Keiko Yoshimitsu, Masahiro Yoshiyama

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS). New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 μg to 4 μg, and decreased significantly as the dosage increased from 8 μg to 24 μg. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 μg to 16 μg, and did not significantly change as the dosage increased from 16 μg to 24 μg. These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.

Original language	English
Pages (from-to)	481-486
Number of pages	6
Journal	Dental materials journal
Volume	26
Issue number	4
DOIs	https://doi.org/10.4012/dmj.26.481
Publication status	Published - Jul 2007

Keywords

Aging
Bone formation
Dose of rhBMP-2

ASJC Scopus subject areas

Ceramics and Composites
Dentistry(all)

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10.4012/dmj.26.481

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title = "Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats",

abstract = "This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS). New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 μg to 4 μg, and decreased significantly as the dosage increased from 8 μg to 24 μg. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 μg to 16 μg, and did not significantly change as the dosage increased from 16 μg to 24 μg. These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.",

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author = "Kozo Yamaji and Masamitsu Kawanami and Atsushi Matsumoto and Tomoomi Odajima and Yoshihiro Nishitani and Kensuke Iwasaka and Keiko Yoshimitsu and Masahiro Yoshiyama",

year = "2007",

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doi = "10.4012/dmj.26.481",

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AU - Yamaji, Kozo

AU - Kawanami, Masamitsu

AU - Matsumoto, Atsushi

AU - Odajima, Tomoomi

AU - Nishitani, Yoshihiro

AU - Iwasaka, Kensuke

AU - Yoshimitsu, Keiko

AU - Yoshiyama, Masahiro

PY - 2007/7

Y1 - 2007/7

N2 - This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS). New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 μg to 4 μg, and decreased significantly as the dosage increased from 8 μg to 24 μg. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 μg to 16 μg, and did not significantly change as the dosage increased from 16 μg to 24 μg. These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.

AB - This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS). New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 μg to 4 μg, and decreased significantly as the dosage increased from 8 μg to 24 μg. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 μg to 16 μg, and did not significantly change as the dosage increased from 16 μg to 24 μg. These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.

KW - Aging

KW - Bone formation

KW - Dose of rhBMP-2

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Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats

Abstract

Keywords

ASJC Scopus subject areas

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