Effects of Epidermal Growth Factor on Mouse Fetal Growth

Koji Odaka; Yuji Hiramatsu; Katsuto Eguchi; Takafumi Kudo

doi:10.1111/j.1447-0756.1993.tb00375.x

Effects of Epidermal Growth Factor on Mouse Fetal Growth

Koji Odaka, Yuji Hiramatsu, Katsuto Eguchi, Takafumi Kudo

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The effects of epidermal growth factor (EGF) on fetal growth were examined in mice. EGF is synthesized in large amounts by the mouse submandibular glands. On the 18th day of gestation, the body weight of fetuses whose mothers had undergone sialoadenectomy (excision of the submandibular glands) was significantly lower than that of controls. However, the maternal‐plasma EGF concentration was not significantly affected by sialoadenectomy. The body weight of fetuses whose mothers were injected with EGF for 7 days during pregnancy was significantly higher than that of controls. Sialoadenectomy altered the blood amino acid concentrations in adult female animals, especially the levels of leucine and isoleucine. These results suggest that EGF influences fetal growth mainly by regulating maternal nutrition.

Original language	English
Pages (from-to)	213-216
Number of pages	4
Journal	Asia‐Oceania Journal of Obstetrics and Gynaecology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1111/j.1447-0756.1993.tb00375.x
Publication status	Published - Jun 1993

Keywords

blood amino acid
epidermal growth factor
fetal growth
submandibular gland

ASJC Scopus subject areas

Obstetrics and Gynaecology

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10.1111/j.1447-0756.1993.tb00375.x

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title = "Effects of Epidermal Growth Factor on Mouse Fetal Growth",

abstract = "The effects of epidermal growth factor (EGF) on fetal growth were examined in mice. EGF is synthesized in large amounts by the mouse submandibular glands. On the 18th day of gestation, the body weight of fetuses whose mothers had undergone sialoadenectomy (excision of the submandibular glands) was significantly lower than that of controls. However, the maternal‐plasma EGF concentration was not significantly affected by sialoadenectomy. The body weight of fetuses whose mothers were injected with EGF for 7 days during pregnancy was significantly higher than that of controls. Sialoadenectomy altered the blood amino acid concentrations in adult female animals, especially the levels of leucine and isoleucine. These results suggest that EGF influences fetal growth mainly by regulating maternal nutrition.",

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T1 - Effects of Epidermal Growth Factor on Mouse Fetal Growth

AU - Odaka, Koji

AU - Hiramatsu, Yuji

AU - Eguchi, Katsuto

AU - Kudo, Takafumi

PY - 1993/6

Y1 - 1993/6

N2 - The effects of epidermal growth factor (EGF) on fetal growth were examined in mice. EGF is synthesized in large amounts by the mouse submandibular glands. On the 18th day of gestation, the body weight of fetuses whose mothers had undergone sialoadenectomy (excision of the submandibular glands) was significantly lower than that of controls. However, the maternal‐plasma EGF concentration was not significantly affected by sialoadenectomy. The body weight of fetuses whose mothers were injected with EGF for 7 days during pregnancy was significantly higher than that of controls. Sialoadenectomy altered the blood amino acid concentrations in adult female animals, especially the levels of leucine and isoleucine. These results suggest that EGF influences fetal growth mainly by regulating maternal nutrition.

AB - The effects of epidermal growth factor (EGF) on fetal growth were examined in mice. EGF is synthesized in large amounts by the mouse submandibular glands. On the 18th day of gestation, the body weight of fetuses whose mothers had undergone sialoadenectomy (excision of the submandibular glands) was significantly lower than that of controls. However, the maternal‐plasma EGF concentration was not significantly affected by sialoadenectomy. The body weight of fetuses whose mothers were injected with EGF for 7 days during pregnancy was significantly higher than that of controls. Sialoadenectomy altered the blood amino acid concentrations in adult female animals, especially the levels of leucine and isoleucine. These results suggest that EGF influences fetal growth mainly by regulating maternal nutrition.

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KW - epidermal growth factor

KW - fetal growth

KW - submandibular gland

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Effects of Epidermal Growth Factor on Mouse Fetal Growth

Abstract

Keywords

ASJC Scopus subject areas

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