Effects of Epidermal Growth Factor on Mouse Fetal Growth

Koji Odaka, Yuji Hiramatsu, Katsuto Eguchi, Takafumi Kudo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The effects of epidermal growth factor (EGF) on fetal growth were examined in mice. EGF is synthesized in large amounts by the mouse submandibular glands. On the 18th day of gestation, the body weight of fetuses whose mothers had undergone sialoadenectomy (excision of the submandibular glands) was significantly lower than that of controls. However, the maternal‐plasma EGF concentration was not significantly affected by sialoadenectomy. The body weight of fetuses whose mothers were injected with EGF for 7 days during pregnancy was significantly higher than that of controls. Sialoadenectomy altered the blood amino acid concentrations in adult female animals, especially the levels of leucine and isoleucine. These results suggest that EGF influences fetal growth mainly by regulating maternal nutrition.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalAsia‐Oceania Journal of Obstetrics and Gynaecology
Issue number2
Publication statusPublished - Jun 1993


  • blood amino acid
  • epidermal growth factor
  • fetal growth
  • submandibular gland

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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