Effects of epidermal growth factor on neonatal growth of rat intestines.

K. Odaka, Y. Hiramatsu, K. Eguchi, T. Kudo

Research output: Contribution to journalArticlepeer-review


The effects of epidermal growth factor (EGF) on neonatal intestines were examined in the rat. In 5-day-old rats, sucrase, trehalase, alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (gamma-GTP) activities in the small intestines were significantly increased after subcutaneous injection of EGF for 3 days (1 microgram/rat/day). gamma-GTP activity was also accelerated after oral EGF administration (2 micrograms/rat/day). Small intestines of 12-day-old rats injected with EGF for 10 days (1 microgram/rat/day) were significantly heavier than those of controls. These results suggest that EGF influences neonatal growth improving enlargement and functional development of their intestines.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalActa medica Okayama
Issue number1
Publication statusPublished - Feb 1994

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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