Effects of gonadotropin releasing hormone and prostaglandin F2α on the reproductive performance in postpartum cows

K. Okuda, W. A. Gaona, K. Sato

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A study was conducted to determine whether treatment with gonadotropin releasing hormone (GnRH) in combination with prostaglandin F2α (PGF2α) could enhance ovarian activity and uterine involution in postpartum dairy cows to reduce the calving interval. Cows were randomly assigned to one of three treatment groups. Cows (n = 8) in Group 1 received 100 μg GnRH intramuscularly (i.m.) twice on Day 20 and Day 35 postpartum, and 25 mg PGF2α i.m. on Day 47 postpartum. Group 2 (n = 8) received a single i.m. injection of 100 μg GnRH on Day 25 postpartum and 25 mg PGF2α i.m. on Day 37 postpartum. The Control Group (n = 9) did not receive hormonal treatment. Palpation per rectum of the reproductive organs and serum progesterone (P) determination were performed twice a week to monitor ovarian activity and uterine involution. Postpartum interval to the first ovulation was short in treated groups (Group 1, 21.0 d; Group 2, 26.3 d) compared with Control Group (30.1 d, P < 0.05). Likewise, mean frequency of ovulation was increased in both treated groups compared with the Control Group (P < 0.05). Cows in treated groups required fewer days to complete uterine involution than in the Control Group. The mean interval to the first service, the conception rate at first service and the number of services per conception showed no significant differences among the three groups, but the mean days from calving to conception were shorter for the treated groups (78.7 d in Group 1; 83.3 d in Group 2) than (109.1 d, P < 0.05) for the Control Group. Our results suggest that combined treatment with GnRH and PGF2α may enhance ovarian activity in the postpartum cow, resulting in improved reproductive performance.

Original languageEnglish
Pages (from-to)823-833
Number of pages11
Issue number4
Publication statusPublished - Apr 1988


  • GnRH
  • PGFα
  • cow
  • postpartum

ASJC Scopus subject areas

  • Small Animals
  • Food Animals
  • Animal Science and Zoology
  • Equine


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