Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly

Junko Goto; Fumio Otsuka; Kenichi Inagaki; Naoko Yamauchi; Jiro Suzuki; Tomoko Miyoshi; Toshio Ogura; Yasuhiko Kamada; Hirofumi Makino

doi:10.1507/endocrj.K08E-215

Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly

Junko Goto, Fumio Otsuka, Kenichi Inagaki, Naoko Yamauchi, Jiro Suzuki, Tomoko Miyoshi, Toshio Ogura, Yasuhiko Kamada, Hirofumi Makino

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We report a rare case of polycystic ovary syndrome (PCOS) complicated with acromegaly due to a growth hormone (GH)-producing pituitary adenoma. Complete removal of the pituitary adenoma successfully reduced circulating levels of GH and insulin-like growth factor (IGF)-l, which, in turn, resulted in the amelioration of gonadal dysfunction, hyperandrogenism, lutenizing hormone hypersecretion, and severe insulin resistance. This clinical complication suggests that activation of systemic GH-IGF-1 axis is potentially involved in the development of PCOS.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Endocrine journal
Volume	56
Issue number	1
DOIs	https://doi.org/10.1507/endocrj.K08E-215
Publication status	Published - 2009

Keywords

Acromegaly
Growth hormone
Hyperglycemia
Insulin-like growth factor-1
Polycystic ovary syndrome

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1507/endocrj.K08E-215

Cite this

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AU - Goto, Junko

AU - Otsuka, Fumio

AU - Inagaki, Kenichi

AU - Yamauchi, Naoko

AU - Suzuki, Jiro

AU - Miyoshi, Tomoko

AU - Ogura, Toshio

AU - Kamada, Yasuhiko

AU - Makino, Hirofumi

PY - 2009

Y1 - 2009

N2 - We report a rare case of polycystic ovary syndrome (PCOS) complicated with acromegaly due to a growth hormone (GH)-producing pituitary adenoma. Complete removal of the pituitary adenoma successfully reduced circulating levels of GH and insulin-like growth factor (IGF)-l, which, in turn, resulted in the amelioration of gonadal dysfunction, hyperandrogenism, lutenizing hormone hypersecretion, and severe insulin resistance. This clinical complication suggests that activation of systemic GH-IGF-1 axis is potentially involved in the development of PCOS.

AB - We report a rare case of polycystic ovary syndrome (PCOS) complicated with acromegaly due to a growth hormone (GH)-producing pituitary adenoma. Complete removal of the pituitary adenoma successfully reduced circulating levels of GH and insulin-like growth factor (IGF)-l, which, in turn, resulted in the amelioration of gonadal dysfunction, hyperandrogenism, lutenizing hormone hypersecretion, and severe insulin resistance. This clinical complication suggests that activation of systemic GH-IGF-1 axis is potentially involved in the development of PCOS.

KW - Acromegaly

KW - Growth hormone

KW - Hyperglycemia

KW - Insulin-like growth factor-1

KW - Polycystic ovary syndrome

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Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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