Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT

S. Isayama; Y. Sugimoto; M. Nishiga; C. Kamei

doi:10.1254/jjp.86.451

Effects of histidine on working memory deficits induced by the 5-HT_1A-receptor agonist 8-OH-DPAT

S. Isayama, Y. Sugimoto, M. Nishiga, C. Kamei

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We investigated the effects of histidine on spatial memory deficits induced by the 5-HT_1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.

Original language	English
Pages (from-to)	451-453
Number of pages	3
Journal	Japanese Journal of Pharmacology
Volume	86
Issue number	4
DOIs	https://doi.org/10.1254/jjp.86.451
Publication status	Published - 2001

Keywords

8-Hydroxy-2-(di-n-propylamino)tetralin
Histidine
Radial maze performance

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1254/jjp.86.451

Cite this

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abstract = "We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.",

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KW - Radial maze performance

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