Effects of hydrogen-rich water on aging periodontal tissues in rats

Takaaki Tomofuji; Yuya Kawabata; Kenta Kasuyama; Yasumasa Endo; Toshiki Yoneda; Mayu Yamane; Tetsuji Azuma; Daisuke Ekuni; Manabu Morita

doi:10.1038/srep05534

Effects of hydrogen-rich water on aging periodontal tissues in rats

Takaaki Tomofuji, Yuya Kawabata, Kenta Kasuyama, Yasumasa Endo, Toshiki Yoneda, Mayu Yamane, Tetsuji Azuma, Daisuke Ekuni, Manabu Morita

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26 Citations (Scopus)

Abstract

Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male Fischer 344 rats (n = 12) were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The rats consumed hydrogen-rich water or distilled water until 16 months of age. The experimental group exhibited lower periodontal oxidative damage at 16 months of age than the control group. Although protein expression of interleukin-1β 2 did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative damage, but not on inflammatory reactions in healthy rats.

Original language	English
Article number	5534
Journal	Scientific reports
Volume	4
DOIs	https://doi.org/10.1038/srep05534
Publication status	Published - Jul 2 2014

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title = "Effects of hydrogen-rich water on aging periodontal tissues in rats",

abstract = "Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male Fischer 344 rats (n = 12) were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The rats consumed hydrogen-rich water or distilled water until 16 months of age. The experimental group exhibited lower periodontal oxidative damage at 16 months of age than the control group. Although protein expression of interleukin-1β 2 did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative damage, but not on inflammatory reactions in healthy rats.",

author = "Takaaki Tomofuji and Yuya Kawabata and Kenta Kasuyama and Yasumasa Endo and Toshiki Yoneda and Mayu Yamane and Tetsuji Azuma and Daisuke Ekuni and Manabu Morita",

note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research (24593153 and 25463243) from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan. The authors report no conflicts of interest related to this study.",

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T1 - Effects of hydrogen-rich water on aging periodontal tissues in rats

AU - Tomofuji, Takaaki

AU - Kawabata, Yuya

AU - Kasuyama, Kenta

AU - Endo, Yasumasa

AU - Yoneda, Toshiki

AU - Yamane, Mayu

AU - Azuma, Tetsuji

AU - Ekuni, Daisuke

AU - Morita, Manabu

N1 - Funding Information: This work was supported by Grants-in-Aid for Scientific Research (24593153 and 25463243) from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan. The authors report no conflicts of interest related to this study.

PY - 2014/7/2

Y1 - 2014/7/2

N2 - Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male Fischer 344 rats (n = 12) were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The rats consumed hydrogen-rich water or distilled water until 16 months of age. The experimental group exhibited lower periodontal oxidative damage at 16 months of age than the control group. Although protein expression of interleukin-1β 2 did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative damage, but not on inflammatory reactions in healthy rats.

AB - Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male Fischer 344 rats (n = 12) were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The rats consumed hydrogen-rich water or distilled water until 16 months of age. The experimental group exhibited lower periodontal oxidative damage at 16 months of age than the control group. Although protein expression of interleukin-1β 2 did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative damage, but not on inflammatory reactions in healthy rats.

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Effects of hydrogen-rich water on aging periodontal tissues in rats

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