Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: Involvement of the expression of 5-HT2A receptor mRNA

Yoshihisa Kitamura; Yoshika Fujitani; Kouhei Kitagawa; Toshiaki Miyazaki; Hidenori Sagara; Hiromu Kawasaki; Kazuhiko Shibata; Toshiaki Sendo; Yutaka Gomita

doi:10.1248/bpb.31.246

Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: Involvement of the expression of 5-HT_2A receptor mRNA

Yoshihisa Kitamura, Yoshika Fujitani, Kouhei Kitagawa, Toshiaki Miyazaki, Hidenori Sagara, Hiromu Kawasaki, Kazuhiko Shibata, Toshiaki Sendo, Yutaka Gomita

University Hospital

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)_2A receptor function in the form of 5-HT_2A receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT_2A receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT_2A receptor mRNA levels may be involved in this phenomenon.

Original language	English
Pages (from-to)	246-249
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	31
Issue number	2
DOIs	https://doi.org/10.1248/bpb.31.246
Publication status	Published - Feb 2008

Keywords

5-HT receptor
Adrenocorticotropic hormone
Bupropion
Forced swim test
Imipramine

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

10.1248/bpb.31.246

Cite this

Kitamura, Y., Fujitani, Y., Kitagawa, K., Miyazaki, T., Sagara, H., Kawasaki, H., Shibata, K., Sendo, T., & Gomita, Y. (2008). Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: Involvement of the expression of 5-HT_2A receptor mRNA. Biological and Pharmaceutical Bulletin, 31(2), 246-249. https://doi.org/10.1248/bpb.31.246

Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: Involvement of the expression of 5-HT_2A receptor mRNA. / Kitamura, Yoshihisa; Fujitani, Yoshika; Kitagawa, Kouhei et al.
In: Biological and Pharmaceutical Bulletin, Vol. 31, No. 2, 02.2008, p. 246-249.

Research output: Contribution to journal › Article › peer-review

Kitamura, Y, Fujitani, Y, Kitagawa, K, Miyazaki, T, Sagara, H, Kawasaki, H, Shibata, K, Sendo, T & Gomita, Y 2008, 'Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: Involvement of the expression of 5-HT_2A receptor mRNA', Biological and Pharmaceutical Bulletin, vol. 31, no. 2, pp. 246-249. https://doi.org/10.1248/bpb.31.246

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