TY - JOUR
T1 - Effects of imipramine on extracellular serotonin and noradrenaline concentrations in ACTH-treated rats
AU - Kitamura, Yoshihisa
AU - Akiyama, Kozue
AU - Hashimoto, Shinji
AU - Kitagawa, Kouhei
AU - Kawasaki, Hiromu
AU - Shibata, Kazuhiko
AU - Shinomiya, Kazuaki
AU - Suemaru, Katsuya
AU - Araki, Hiroaki
AU - Sendo, Toshiaki
AU - Gomita, Yutaka
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/7/2
Y1 - 2007/7/2
N2 - We investigated the effect of imipramine on extracellular serotonin (5-HT) and noradrenaline concentrations in the medial prefrontal cortex of rats treated with adrenocorticotropic hormone (ACTH) for 14 days using in vivo microdialysis. Chronic ACTH treatment did not affect basal extracellular 5-HT and noradrenaline concentrations compared with chronic saline treatment. Acute imipramine treatment plus chronic ACTH treatment significantly increased extracellular 5-HT concentrations, compared with imipramine treatment alone. 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a 5-HT1A receptors full agonist, caused a significant decrease in extracellular 5-HT concentrations. However, its inhibitory effect was attenuated by the treatment with ACTH for 14 days. These findings suggest that chronic treatment with ACTH enhances the increasing effect release of 5-HT by imipramine through the desensitization of somatodendritic 5-HT1A autoreceptors.
AB - We investigated the effect of imipramine on extracellular serotonin (5-HT) and noradrenaline concentrations in the medial prefrontal cortex of rats treated with adrenocorticotropic hormone (ACTH) for 14 days using in vivo microdialysis. Chronic ACTH treatment did not affect basal extracellular 5-HT and noradrenaline concentrations compared with chronic saline treatment. Acute imipramine treatment plus chronic ACTH treatment significantly increased extracellular 5-HT concentrations, compared with imipramine treatment alone. 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a 5-HT1A receptors full agonist, caused a significant decrease in extracellular 5-HT concentrations. However, its inhibitory effect was attenuated by the treatment with ACTH for 14 days. These findings suggest that chronic treatment with ACTH enhances the increasing effect release of 5-HT by imipramine through the desensitization of somatodendritic 5-HT1A autoreceptors.
KW - 5-HT receptor
KW - 8-hydroxy-2-di-n-propylamino tetralin
KW - Adrenocorticotropic hormone
KW - Imipramine
KW - Microdialysis
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U2 - 10.1016/j.ejphar.2007.03.012
DO - 10.1016/j.ejphar.2007.03.012
M3 - Article
C2 - 17459373
AN - SCOPUS:34249037043
SN - 0014-2999
VL - 566
SP - 113
EP - 116
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -