Effects of NMDA antagonist MK-801 on radial maze performance in Zucker rats

Miyuki Nishiga; Yoko Fujii; Yukio Sugimoto; Masako Konishi; Chiaki Kamei

doi:10.1016/S0006-8993(02)03012-3

Effects of NMDA antagonist MK-801 on radial maze performance in Zucker rats

Miyuki Nishiga, Yoko Fujii, Yukio Sugimoto, Masako Konishi, Chiaki Kamei

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We examined the participation of the NMDA receptor in the histaminergic system using radial maze performance in Zucker rats. Although pyrilamine caused a significant effect on spatial memory deficit in lean rats, no significant spatial memory deficit was observed in obese rats. On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. These results indicate that the histaminergic neuron is not closely related with the radial maze performance in obese rats. In addition, the potent effect of MK-801 observed in obese rats compared with lean rats may be responsible for the activation of NMDA receptors in obese rats.

Original language	English
Pages (from-to)	127-129
Number of pages	3
Journal	Brain Research
Volume	950
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)03012-3
Publication status	Published - Sept 20 2002

Keywords

Learning and memory
MK-801
Pyrilamine
Radial maze
Zucker obese rat

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(02)03012-3

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title = "Effects of NMDA antagonist MK-801 on radial maze performance in Zucker rats",

abstract = "We examined the participation of the NMDA receptor in the histaminergic system using radial maze performance in Zucker rats. Although pyrilamine caused a significant effect on spatial memory deficit in lean rats, no significant spatial memory deficit was observed in obese rats. On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. These results indicate that the histaminergic neuron is not closely related with the radial maze performance in obese rats. In addition, the potent effect of MK-801 observed in obese rats compared with lean rats may be responsible for the activation of NMDA receptors in obese rats.",

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AU - Nishiga, Miyuki

AU - Fujii, Yoko

AU - Sugimoto, Yukio

AU - Konishi, Masako

AU - Kamei, Chiaki

PY - 2002/9/20

Y1 - 2002/9/20

N2 - We examined the participation of the NMDA receptor in the histaminergic system using radial maze performance in Zucker rats. Although pyrilamine caused a significant effect on spatial memory deficit in lean rats, no significant spatial memory deficit was observed in obese rats. On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. These results indicate that the histaminergic neuron is not closely related with the radial maze performance in obese rats. In addition, the potent effect of MK-801 observed in obese rats compared with lean rats may be responsible for the activation of NMDA receptors in obese rats.

AB - We examined the participation of the NMDA receptor in the histaminergic system using radial maze performance in Zucker rats. Although pyrilamine caused a significant effect on spatial memory deficit in lean rats, no significant spatial memory deficit was observed in obese rats. On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. These results indicate that the histaminergic neuron is not closely related with the radial maze performance in obese rats. In addition, the potent effect of MK-801 observed in obese rats compared with lean rats may be responsible for the activation of NMDA receptors in obese rats.

KW - Learning and memory

KW - MK-801

KW - Pyrilamine

KW - Radial maze

KW - Zucker obese rat

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Effects of NMDA antagonist MK-801 on radial maze performance in Zucker rats

Abstract

Keywords

ASJC Scopus subject areas

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