Effects of NMDA antagonist MK-801 on radial maze performance in Zucker rats

Miyuki Nishiga, Yoko Fujii, Yukio Sugimoto, Masako Konishi, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We examined the participation of the NMDA receptor in the histaminergic system using radial maze performance in Zucker rats. Although pyrilamine caused a significant effect on spatial memory deficit in lean rats, no significant spatial memory deficit was observed in obese rats. On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. These results indicate that the histaminergic neuron is not closely related with the radial maze performance in obese rats. In addition, the potent effect of MK-801 observed in obese rats compared with lean rats may be responsible for the activation of NMDA receptors in obese rats.

Original languageEnglish
Pages (from-to)127-129
Number of pages3
JournalBrain Research
Issue number1-2
Publication statusPublished - Sept 20 2002


  • Learning and memory
  • MK-801
  • Pyrilamine
  • Radial maze
  • Zucker obese rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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