Abstract
Kokubo's simulated body fluid (SBF) has been extensively used for screening to distinguish bioactive materials. The present study examined the effects of organic acids and albumin in the SBF on apatite formation on glass and titanium substrates. Titanium substrates were subject to a H2O2 treatment and subsequent heating to prepare bioactive titania layers. Apatite formation was then examined after soaking the substrates in both SBF and modified SBF containing organic components such as succinic acid, tartaric acid, citric acid and albumin. Calcium-chelate formation due to the organics reduced free calcium ion concentration. The induction time of apatite nucleation on the titania surface was delayed in SBF containing the organic acids. The reduction in the free calcium ion concentration suppressed the apatite nucleation.
| Original language | English |
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| Pages | 103-110 |
| Number of pages | 8 |
| Publication status | Published - Dec 1 2003 |
| Event | Bioceramics: Materials and Applications IV, Proceedings - Nashville, TN, United States Duration: Apr 27 2003 → Apr 30 2003 |
Conference
| Conference | Bioceramics: Materials and Applications IV, Proceedings |
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| Country/Territory | United States |
| City | Nashville, TN |
| Period | 4/27/03 → 4/30/03 |
ASJC Scopus subject areas
- Ceramics and Composites
- Materials Chemistry