Effects of salicylic acid on mushroom tyrosinase and B16 melanoma cells

Sadaaki Tamura; Teruhiko Nitoda; Isao Kubo

doi:10.1515/znc-2007-3-412

Effects of salicylic acid on mushroom tyrosinase and B16 melanoma cells

Sadaaki Tamura, Teruhiko Nitoda, Isao Kubo

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Salicylic acid slightly inhibited the oxidation of L-3,4- dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.

Original language	English
Pages (from-to)	227-233
Number of pages	7
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	62
Issue number	3-4
DOIs	https://doi.org/10.1515/znc-2007-3-412
Publication status	Published - 2007
Externally published	Yes

Keywords

B16-F10 melanoma cells
Salicylic acid
Tyrosinase

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Effects of salicylic acid on mushroom tyrosinase and B16 melanoma cells",

abstract = "Salicylic acid slightly inhibited the oxidation of L-3,4- dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.",

keywords = "B16-F10 melanoma cells, Salicylic acid, Tyrosinase",

author = "Sadaaki Tamura and Teruhiko Nitoda and Isao Kubo",

note = "Funding Information: The authors are indebted to Ms. I. Hori for performing the cell-free tyrosinase assay at an earlier stage of the work. T. N. thanks Japan Society for the Promotion of Science for financial support during his study at UC, Berkeley.",

year = "2007",

doi = "10.1515/znc-2007-3-412",

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volume = "62",

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journal = "Zeitschrift fur Naturforschung - Section C Journal of Biosciences",

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T1 - Effects of salicylic acid on mushroom tyrosinase and B16 melanoma cells

AU - Tamura, Sadaaki

AU - Nitoda, Teruhiko

AU - Kubo, Isao

N1 - Funding Information: The authors are indebted to Ms. I. Hori for performing the cell-free tyrosinase assay at an earlier stage of the work. T. N. thanks Japan Society for the Promotion of Science for financial support during his study at UC, Berkeley.

PY - 2007

Y1 - 2007

N2 - Salicylic acid slightly inhibited the oxidation of L-3,4- dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.

AB - Salicylic acid slightly inhibited the oxidation of L-3,4- dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.

KW - B16-F10 melanoma cells

KW - Salicylic acid

KW - Tyrosinase

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ER -

Effects of salicylic acid on mushroom tyrosinase and B16 melanoma cells

Abstract

Keywords

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