Salicylic acid slightly inhibited the oxidation of L-3,4- dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.
|Number of pages
|Zeitschrift fur Naturforschung - Section C Journal of Biosciences
|Published - 2007
- B16-F10 melanoma cells
- Salicylic acid
ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology