Effects of salicylic acid on mushroom tyrosinase and B16 melanoma cells

Sadaaki Tamura, Teruhiko Nitoda, Isao Kubo

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Salicylic acid slightly inhibited the oxidation of L-3,4- dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Issue number3-4
Publication statusPublished - 2007
Externally publishedYes


  • B16-F10 melanoma cells
  • Salicylic acid
  • Tyrosinase

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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