Effects of the 5-HT1A receptor agonist tandospirone on ACTH-induced sleep disturbance in rats

Ryuki Tsutsui, Kazuaki Shinomiya, Toshiaki Sendo, Yoshihisa Kitamura, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The aim of this study was to compare the effect of the serotonin (5-HT)1A receptor agonist tandospirone versus that of the benzodiazepine hypnotic flunitrazepam in a rat model of long-term adrenocorticotropic hormone (ACTH)-induced sleep disturbance. Rats implanted with electrodes for recording electroencephalogram and electromyogram were injected with ACTH once daily at a dose of 100 μg/rat. Administration of ACTH for 10 d caused a significant increase in sleep latency, decrease in non-rapid eye movement (non-REM) sleep time, and increase in wake time. Tandospirone caused a significant decrease in sleep latency and increase in non-REM sleep time in rats treated with ACTH. The effect of tandospirone on sleep patterns was antagonized by the 5-HT1A receptor antagonist WAY-100635. In contrast, flunitrazepam had no significant effect on sleep parameters in ACTH-treated rats. These results clearly indicate that long-term administration of ACTH causes sleep disturbance, and stimulating the 5-HT1A receptor by tandospirone may be efficacious for improving sleep in cases in which benzodiazepine hypnotics are ineffective.

Original languageEnglish
Pages (from-to)884-888
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Issue number6
Publication statusPublished - Jun 1 2015


  • Adrenocorticotropic hormone
  • Gamma-aminobutyric acid
  • Serotonin (5-HT) receptor
  • Sleep disturbance

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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