TY - JOUR
T1 - Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines
T2 - The 'power rehabilitation' program
AU - Murakami, Shin Ichiro
AU - Otsuki, Takemi
AU - Maeda, Megumi
AU - Miura, Yoshie
AU - Morii, Seiko
AU - Kiyokane, Kenji
AU - Hayakawa, Shin Ichi
AU - Maeda, Atsushi
AU - Imakawa, Takayo
AU - Harada, Shunpei
AU - Handa, Torataro
AU - Nishimura, Yasumitsu
AU - Murakami, Shuko
AU - Kumagai, Naoko
AU - Hayashi, Hiroaki
AU - Chen, Ying
AU - Suemori, Shin Ichiro
AU - Fukushima, Yumiko
AU - Nishida, Seikoh
AU - Fukushima, Keisuke
PY - 2009
Y1 - 2009
N2 - The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established as a rehabilitation program. To investigate the individual factors which influence the effects of 'Power Rehabilitation', single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene and the ciliary neurotrophic factor (CNTF) gene were analyzed, and the relationship between SNP patterns and the effects of 'Power Rehabilitation' was evaluated. 'Power Rehabilitation' had an effect on the physiological functions involved in the activities of daily life (ADL) rather than muscle strength and size. In addition, certain SNP patterns showed better improvement of parameters associated with the effects of 'Power Rehabilitation' as analyzed by comparison between SNP patterns and factor analysis. Large scale analyses are required to ensure this tendency and to discover individual factors which may help to promote the health and QOL of the aged population.
AB - The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established as a rehabilitation program. To investigate the individual factors which influence the effects of 'Power Rehabilitation', single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene and the ciliary neurotrophic factor (CNTF) gene were analyzed, and the relationship between SNP patterns and the effects of 'Power Rehabilitation' was evaluated. 'Power Rehabilitation' had an effect on the physiological functions involved in the activities of daily life (ADL) rather than muscle strength and size. In addition, certain SNP patterns showed better improvement of parameters associated with the effects of 'Power Rehabilitation' as analyzed by comparison between SNP patterns and factor analysis. Large scale analyses are required to ensure this tendency and to discover individual factors which may help to promote the health and QOL of the aged population.
KW - Low-resistance training
KW - Rehabilitation
KW - Single nucleotide polymorphism
KW - Vitmin D receptor
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U2 - 10.3892/ijmm_00000104
DO - 10.3892/ijmm_00000104
M3 - Article
C2 - 19082510
AN - SCOPUS:61749097273
SN - 1107-3756
VL - 23
SP - 81
EP - 88
JO - International Journal of Molecular Medicine
JF - International Journal of Molecular Medicine
IS - 1
ER -