Efficacy of mefloquine treatment and genetic profiles in uncomplicated plasmodium falciparum malaria in southern Lao PDR

Hiromu Toma; Toshimitsu Hatabu; Viengxay Vanisaveth; M. Kaiissar Mannoor; Hisami Watanabe; Changchun Li; Jun Kobayashi; Samlane Phompida; Shigeyuki Kano; Yoshiya Sato

Efficacy of mefloquine treatment and genetic profiles in uncomplicated plasmodium falciparum malaria in southern Lao PDR

Hiromu Toma, Toshimitsu Hatabu, Viengxay Vanisaveth, M. Kaiissar Mannoor, Hisami Watanabe, Changchun Li, Jun Kobayashi, Samlane Phompida, Shigeyuki Kano, Yoshiya Sato

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a 28-day follow-up of 17 Laotian patients diagnosed with uncomplicated Plasmodium falciparum malaria treated with mefloquine (Mephaquine ®, MQ) alone to determine the efficacy. All patients were completely cured with MQ, without reappearance of asexual stage parasitemia at follow-up. Of the 7 isolates tested for genotypic analysis, one isolate was a Y86 mutant type of the pfmdr1 gene, the others were N86 wild. These findings suggest no MQ resistance in the study area possibly because the drug is rarely used in southern Lao PDR.

Original language	English
Pages (from-to)	759-763
Number of pages	5
Journal	Southeast Asian Journal of Tropical Medicine and Public Health
Volume	42
Issue number	4
Publication status	Published - Jul 2011
Externally published	Yes

Keywords

Genetic profile
Lao PDR
Mefloquine
Plasmodium falciparum

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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AU - Toma, Hiromu

AU - Hatabu, Toshimitsu

AU - Vanisaveth, Viengxay

AU - Mannoor, M. Kaiissar

AU - Watanabe, Hisami

AU - Li, Changchun

AU - Kobayashi, Jun

AU - Phompida, Samlane

AU - Kano, Shigeyuki

AU - Sato, Yoshiya

PY - 2011/7

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Efficacy of mefloquine treatment and genetic profiles in uncomplicated plasmodium falciparum malaria in southern Lao PDR

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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