Efficacy of pleurodesis for malignant pleural effusions in breast cancer patients

T. Hirata, K. Yonemori, A. Hirakawa, C. Shimizu, K. Tamura, M. Ando, N. Katsumata, M. Tanimoto, Y. Fujiwara

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


This study retrospectively compared long-term outcomes between two groups of breast cancer patients with malignant pleural effusion (MPE): those receiving only systemic therapy (ST) and those receiving ST following initial pleurodesis (P-ST). We identified 180 breast cancer patients from the National Cancer Center Hospital (Tokyo, Japan) database who had received ST and P-ST as an initial treatment for MPE between 1997 and 2008 for study inclusion. Pleural progression-free survival (PPFS) was defined as the time from ST in the ST group and from pleurodesis in the P-ST group to the first observation of pleural progression or death from any cause. Of the 180 patients, 78 received ST and 102 received P-ST after MPE diagnosis. Median duration of follow-up was 12.7 months (range 0.9-80.1 months). Median PPFS for the ST group and the P-ST group was 4.1 and 8.5 months, respectively. The difference in PPFS between the two groups was statistically significant (p<0.001) and the hazard ratio after adjusting for prognostic factors in the P-ST group relative to the ST group was 0.24. Our results suggest that the efficacy of P-ST may be superior to that of ST alone with respect to local control of pleural effusions in breast cancer patients. Copyright

Original languageEnglish
Pages (from-to)1425-1430
Number of pages6
JournalEuropean Respiratory Journal
Issue number6
Publication statusPublished - Dec 1 2011
Externally publishedYes


  • Breast cancer
  • Malignant pleural effusion
  • Pleural progression-free survival
  • Pleurodesis
  • Systemic therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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