Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia

Kumiko Hirokoshi, Yohei Maeshima, Kazuko Kobayashi, Eiji Matsuura, Hitoshi Sugiyama, Yasushi Yamasaki, Hisashi Masuyama, Yuji Hiramatsu, Hirofumi Makino

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background: An imbalance of angiogenesis-associated factors may predispose to preeclampsia. Here, we determined the ratio of serum concentration of soluble fms-like tyrosine kinase 1 (sFlt-1), a natural inhibitor of pro-angiogenic vascular endothelial growth factor (VEGF) relative to angiopoietin-2 (Ang-2), a natural antagonist of angiopoietin-1 (Ang-1) involved in promoting angiogenesis in the presence of VEGF, in women with preeclampsia. Methods: The levels of serum sFlt-1 and Ang-2 were measured by enzyme-linked immunosorbent assay. Results: Significant decrease of serum Ang-2 and the increase of sFlt-1 were observed in women with preeclampsia as compared to healthy pregnant women. The serum sFlt-1/Ang-2 ratio was strikingly increased in preeclamptic women in contrast to healthy pregnant women exhibiting lower value similar to non-pregnant women. The serum sFlt-1 concentrations tended to positively correlate with mean blood pressure (BP) in preeclamptic women, but not in healthy pregnant women. A cut-off value >0.25 in the serum sFlt-1/Ang-2 ratio showed 87.1% sensitivity and 82.8% specificity in differentiating preeclamptic women from healthy pregnant women. Conclusion: The serum sFlt-1/Ang-2 ratio is significantly elevated in preeclamptic women as compared to healthy pregnant women. Remarkable difference of sFlt-1/Ang-2 ratio between these two groups with excellent specificity and sensitivity suggests the clinical usefulness of the serum sFlt-1/Ang-2 ratio in diagnosing and potentially predicting the onset of preeclampsia.

Original languageEnglish
Pages (from-to)c43-c50
JournalNephron - Clinical Practice
Issue number1
Publication statusPublished - May 2007


  • Angiogenesis
  • Angiopoietin-2
  • Preeclampsia
  • sFlt-1
  • sFlt-1/Ang-2 ratio

ASJC Scopus subject areas

  • Nephrology


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