TY - JOUR
T1 - Elevation of plasma interleukin-6 level in patients undergoing oral and maxillofacial surgery
AU - Miyawaki, Takuya
AU - Maeda, Shigeru
AU - Shimada, Masahiko
PY - 1996
Y1 - 1996
N2 - Objective. The purpose of this study was to evaluate the response of peripheral interleukin-6 associated with oral and maxillofacial surgery. Study design. Fifteen patients undergoing elective oral and maxillofacial surgery were studied. We investigated the change in plasma interleukin-6 level during and after surgery and the correlation between plasma interleukin-6 level and surgical procedure. Plasma interleukin-6 levels were measured by enzyme-linked immunosorbent assay. Statistical significance was determined by nonparametric methods. Results. Elevation of plasma interleukin-6 level was detected at 2 to 6 hours after incision and observed to reach a peak level within 6 hours after the end of surgery. There were significant correlations between plasma interleukin-6 level and duration of surgery or response of C-reactive protein. Conclusion. The results suggested that interleukin-6 would be released by surgical injury and elevation of plasma interleukin-6 level would be associated with magnitude of tissue damage in oral and maxillofacial surgery.
AB - Objective. The purpose of this study was to evaluate the response of peripheral interleukin-6 associated with oral and maxillofacial surgery. Study design. Fifteen patients undergoing elective oral and maxillofacial surgery were studied. We investigated the change in plasma interleukin-6 level during and after surgery and the correlation between plasma interleukin-6 level and surgical procedure. Plasma interleukin-6 levels were measured by enzyme-linked immunosorbent assay. Statistical significance was determined by nonparametric methods. Results. Elevation of plasma interleukin-6 level was detected at 2 to 6 hours after incision and observed to reach a peak level within 6 hours after the end of surgery. There were significant correlations between plasma interleukin-6 level and duration of surgery or response of C-reactive protein. Conclusion. The results suggested that interleukin-6 would be released by surgical injury and elevation of plasma interleukin-6 level would be associated with magnitude of tissue damage in oral and maxillofacial surgery.
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U2 - 10.1016/s1079-2104(96)80140-5
DO - 10.1016/s1079-2104(96)80140-5
M3 - Article
C2 - 8850476
AN - SCOPUS:0029678032
SN - 2212-4403
VL - 81
SP - 15
EP - 20
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 1
ER -