Ellagitannins and simple phenolics from the halophytic plant Tamarix nilotica

Mohamed A.A. Orabi, Sabry A.H. Zidan, Gouda H. Attia, Hamad S. Alyami, Katsuyoshi Matsunami, Tsutomu Hatano

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Three new [nilotinins M8‒M10 (1‒3)] and two known [tamarixinin A (4) and gemin D (5)] ellagitannins and seven simple phenolics [gallic acid (6), methyl gallate (7), 3,4-di-O-methylgallic acid (8), ellagic acid (9), 3-O-methylellagic acid (10), methyl ferulate 3-O-sulphate (11), and 7,4′-di-O-methylkaempferol (12)] were isolated from the halophytic plant Tamarix nilotica (Ehrenb.) Bunge (Tamaricaceae). Their structures were determined based on intensive spectroscopic studies and comparisons with reported data. Compounds 4, and 6–8 were evaluated for their cytotoxicity against lung adenocarcinoma cell line (A549) and anti-leishmanial activity against Leishmania major. Compounds 4, 6 and 7 showed promising cytotoxic properties against A549 (IC50 29 ± 2.3, 10.5 ± 0.7, and 20.7 ± 1.9 μg/mL), while compounds 4 and 7 showed higher growth-inhibitory effects against L. major promastigotes (IC50 40.5 ± 2.7 and 38.4 ± 2.5 μg/mL), as compared with the standards doxorubicin (IC50 0.42 µg/mL) and miltefosine (IC50 9.43 μg/mL), respectively.

Original languageEnglish
JournalNatural Product Research
Publication statusAccepted/In press - 2020


  • A549
  • Tamaricaceae
  • Tamarix nilotica
  • cytotoxicity
  • leishmania major
  • phenolics
  • tannins

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry


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