Emergence of daptomycin-resistant Staphylococcus aureus during treatment

Hideharu Hagiya; Yuto Haruki; Taeko Uchida; Tomoko Wada; Sumiko Shiota; Tomoharu Ishida; Hiroko Ogawa; Tomoko Murase; Fumio Otsuka

doi:10.2169/internalmedicine.55.4763

Emergence of daptomycin-resistant Staphylococcus aureus during treatment

Hideharu Hagiya, Yuto Haruki, Taeko Uchida, Tomoko Wada, Sumiko Shiota, Tomoharu Ishida, Hiroko Ogawa, Tomoko Murase, Fumio Otsuka

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A 68-year-old man with persistent bacteremia accompanying a large iliopsoas abscess, vertebral osteomyelitis, discitis and central venous port infection caused by methicillin-resistant Staphylococcus aureus (MRSA) was admitted to our hospital. During the course of treatment, the emergence of a daptomycin (DAP)-resistant MRSA strain was confirmed; the minimum inhibitory concentration was 1 to 2 μg/mL for vancomycin and more than 1 μg/mL for DAP. Although the bacterial cell wall was not significantly thickened, an increased positive surface charge and single-nucleotide polymorphism within mprF have been confirmed in DAPresistant strains. Still rare, but clinicians need to be cautious of the emergence of DAP-resistant MRSA during treatment.

Original language	English
Pages (from-to)	73-78
Number of pages	6
Journal	Internal Medicine
Volume	55
Issue number	1
DOIs	https://doi.org/10.2169/internalmedicine.55.4763
Publication status	Published - Jan 1 2016

Keywords

Bacterial surface charge
Cell wall thickness
Creeping
MprF
Single-nucleotide polymorphism (SNP)
Staphylococcus aureus bacteremia (SAB)

ASJC Scopus subject areas

Internal Medicine

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title = "Emergence of daptomycin-resistant Staphylococcus aureus during treatment",

abstract = "A 68-year-old man with persistent bacteremia accompanying a large iliopsoas abscess, vertebral osteomyelitis, discitis and central venous port infection caused by methicillin-resistant Staphylococcus aureus (MRSA) was admitted to our hospital. During the course of treatment, the emergence of a daptomycin (DAP)-resistant MRSA strain was confirmed; the minimum inhibitory concentration was 1 to 2 μg/mL for vancomycin and more than 1 μg/mL for DAP. Although the bacterial cell wall was not significantly thickened, an increased positive surface charge and single-nucleotide polymorphism within mprF have been confirmed in DAPresistant strains. Still rare, but clinicians need to be cautious of the emergence of DAP-resistant MRSA during treatment.",

keywords = "Bacterial surface charge, Cell wall thickness, Creeping, MprF, Single-nucleotide polymorphism (SNP), Staphylococcus aureus bacteremia (SAB)",

author = "Hideharu Hagiya and Yuto Haruki and Taeko Uchida and Tomoko Wada and Sumiko Shiota and Tomoharu Ishida and Hiroko Ogawa and Tomoko Murase and Fumio Otsuka",

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AU - Hagiya, Hideharu

AU - Haruki, Yuto

AU - Uchida, Taeko

AU - Wada, Tomoko

AU - Shiota, Sumiko

AU - Ishida, Tomoharu

AU - Ogawa, Hiroko

AU - Murase, Tomoko

AU - Otsuka, Fumio

PY - 2016/1/1

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N2 - A 68-year-old man with persistent bacteremia accompanying a large iliopsoas abscess, vertebral osteomyelitis, discitis and central venous port infection caused by methicillin-resistant Staphylococcus aureus (MRSA) was admitted to our hospital. During the course of treatment, the emergence of a daptomycin (DAP)-resistant MRSA strain was confirmed; the minimum inhibitory concentration was 1 to 2 μg/mL for vancomycin and more than 1 μg/mL for DAP. Although the bacterial cell wall was not significantly thickened, an increased positive surface charge and single-nucleotide polymorphism within mprF have been confirmed in DAPresistant strains. Still rare, but clinicians need to be cautious of the emergence of DAP-resistant MRSA during treatment.

AB - A 68-year-old man with persistent bacteremia accompanying a large iliopsoas abscess, vertebral osteomyelitis, discitis and central venous port infection caused by methicillin-resistant Staphylococcus aureus (MRSA) was admitted to our hospital. During the course of treatment, the emergence of a daptomycin (DAP)-resistant MRSA strain was confirmed; the minimum inhibitory concentration was 1 to 2 μg/mL for vancomycin and more than 1 μg/mL for DAP. Although the bacterial cell wall was not significantly thickened, an increased positive surface charge and single-nucleotide polymorphism within mprF have been confirmed in DAPresistant strains. Still rare, but clinicians need to be cautious of the emergence of DAP-resistant MRSA during treatment.

KW - Bacterial surface charge

KW - Cell wall thickness

KW - Creeping

KW - MprF

KW - Single-nucleotide polymorphism (SNP)

KW - Staphylococcus aureus bacteremia (SAB)

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Emergence of daptomycin-resistant Staphylococcus aureus during treatment

Abstract

Keywords

ASJC Scopus subject areas

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