TY - JOUR
T1 - Enantiomerically pure 1,2-bis(isopropylmethylphosphino)benzene and its use in highly enantioselective Rh-catalyzed asymmetric hydrogenation
AU - Miura, Tomoya
AU - Imamoto, Tsuneo
N1 - Funding Information:
Acknowledgment: The authors wish to thank Mr. M. Nishiura for X-ray analyses. They are grateful also to Nippon Chemical Industrial Co., Ltd. for a gift of 1,2-bis(dimethoxyphosphoryl)benzene. This work was supported by The Japan Society for the Promotion of Science under "Research for the Future" Program (Grant JSPS-RFTF96P00304).
PY - 1999/6/25
Y1 - 1999/6/25
N2 - A new P-chiral phosphine ligand with a 1,2-phenylene unit, (S,S)-1,2- bis(isoprophylmethylphosphino)benzene, has been synthesized from 1,2- bis(methylphosphino)benzene. Its rhodium complex is highly effective in asymmetric hydrogenation of dehydroamino acid methyl esters to provide enatioselectivities of up to 98%.
AB - A new P-chiral phosphine ligand with a 1,2-phenylene unit, (S,S)-1,2- bis(isoprophylmethylphosphino)benzene, has been synthesized from 1,2- bis(methylphosphino)benzene. Its rhodium complex is highly effective in asymmetric hydrogenation of dehydroamino acid methyl esters to provide enatioselectivities of up to 98%.
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U2 - 10.1016/S0040-4039(99)00856-4
DO - 10.1016/S0040-4039(99)00856-4
M3 - Article
AN - SCOPUS:0033603422
SN - 0040-4039
VL - 40
SP - 4833
EP - 4836
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 26
ER -