Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6

Shizuo Narimatsu, Rika Kato, Toshiharu Horie, Satoshi Ono, Michio Tsutsui, Yoshiyasu Yabusaki, Shigeru Ohmori, Mitsukazu Kitada, Takao Ichioka, Noriaki Shimada, Ryuichi Kato, Tsutomu Ishikawa

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