Endogenous gamma-interferon activates thymidine phosphorylase in colorectal cancer tissue

H. Iwagaki; A. Hizuta; K. Mori; T. Yoshino; K. Kawahara; N. Tanaka; K. Orita

Endogenous gamma-interferon activates thymidine phosphorylase in colorectal cancer tissue

H. Iwagaki, A. Hizuta, K. Mori, T. Yoshino, K. Kawahara, N. Tanaka, K. Orita

Research output: Contribution to journal › Article › peer-review

Abstract

We measured neopterin (NPT), an indirect marker of gamma (γ)-interferon, and the activity of thymidine phosphorylase (dThdPase) in the advancing front of colorectal carcinoma and in normal mucosa. Cancer showed a higher concentration of NPT than normal mucosa and also showed significantly higher (p < 0.0001) dThdPase activity than normal mucosa. There was a strong correlation between NPT concentration and dThdPase activity in cancerous and normal mucosa. These results suggest that endogenous γ-interferon could activate dThdPase activity, which is essential to nucleic acid metabolism because it regulates the availability of thymidine.

Original language	English
Pages (from-to)	345-352
Number of pages	8
Journal	Research Communications in Molecular Pathology and Pharmacology
Volume	87
Issue number	3
Publication status	Published - Jan 1 1995

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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abstract = "We measured neopterin (NPT), an indirect marker of gamma (γ)-interferon, and the activity of thymidine phosphorylase (dThdPase) in the advancing front of colorectal carcinoma and in normal mucosa. Cancer showed a higher concentration of NPT than normal mucosa and also showed significantly higher (p < 0.0001) dThdPase activity than normal mucosa. There was a strong correlation between NPT concentration and dThdPase activity in cancerous and normal mucosa. These results suggest that endogenous γ-interferon could activate dThdPase activity, which is essential to nucleic acid metabolism because it regulates the availability of thymidine.",

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T1 - Endogenous gamma-interferon activates thymidine phosphorylase in colorectal cancer tissue

AU - Iwagaki, H.

AU - Hizuta, A.

AU - Mori, K.

AU - Yoshino, T.

AU - Kawahara, K.

AU - Tanaka, N.

AU - Orita, K.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - We measured neopterin (NPT), an indirect marker of gamma (γ)-interferon, and the activity of thymidine phosphorylase (dThdPase) in the advancing front of colorectal carcinoma and in normal mucosa. Cancer showed a higher concentration of NPT than normal mucosa and also showed significantly higher (p < 0.0001) dThdPase activity than normal mucosa. There was a strong correlation between NPT concentration and dThdPase activity in cancerous and normal mucosa. These results suggest that endogenous γ-interferon could activate dThdPase activity, which is essential to nucleic acid metabolism because it regulates the availability of thymidine.

AB - We measured neopterin (NPT), an indirect marker of gamma (γ)-interferon, and the activity of thymidine phosphorylase (dThdPase) in the advancing front of colorectal carcinoma and in normal mucosa. Cancer showed a higher concentration of NPT than normal mucosa and also showed significantly higher (p < 0.0001) dThdPase activity than normal mucosa. There was a strong correlation between NPT concentration and dThdPase activity in cancerous and normal mucosa. These results suggest that endogenous γ-interferon could activate dThdPase activity, which is essential to nucleic acid metabolism because it regulates the availability of thymidine.

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Endogenous gamma-interferon activates thymidine phosphorylase in colorectal cancer tissue

Abstract

ASJC Scopus subject areas

UN SDGs

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