Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells

R. Tamura; H. K. Takahashi; D. Xue; S. Kubo; S. Saito; M. Nishibori; H. Iwagaki; N. Tanaka

doi:10.1177/147323000403200104

Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells

R. Tamura, H. K. Takahashi, D. Xue, S. Kubo, S. Saito, M. Nishibori, H. Iwagaki, N. Tanaka

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-α and interferon-γ. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.

Original language	English
Pages (from-to)	25-32
Number of pages	8
Journal	Journal of International Medical Research
Volume	32
Issue number	1
DOIs	https://doi.org/10.1177/147323000403200104
Publication status	Published - 2004

Keywords

B7.2
Bu-Zhong-Yi-Qi-Tang (TJ-41)
Co-stimulatory molecule
Intercellular adhesion molecule-1 (ICAM-1)
Interferon-γ
Interleukin-18
Tumour necrosis factor-α

ASJC Scopus subject areas

Biochemistry
Cell Biology
Biochemistry, medical

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10.1177/147323000403200104

Cite this

Tamura, R., Takahashi, H. K., Xue, D., Kubo, S., Saito, S., Nishibori, M., Iwagaki, H., & Tanaka, N. (2004). Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells. Journal of International Medical Research, 32(1), 25-32. https://doi.org/10.1177/147323000403200104

Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells. / Tamura, R.; Takahashi, H. K.; Xue, D. et al.
In: Journal of International Medical Research, Vol. 32, No. 1, 2004, p. 25-32.

Research output: Contribution to journal › Article › peer-review

Tamura, R, Takahashi, HK, Xue, D, Kubo, S, Saito, S , Nishibori, M, Iwagaki, H & Tanaka, N 2004, 'Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells', Journal of International Medical Research, vol. 32, no. 1, pp. 25-32. https://doi.org/10.1177/147323000403200104

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abstract = "Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-α and interferon-γ. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.",

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AU - Takahashi, H. K.

AU - Xue, D.

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AU - Saito, S.

AU - Nishibori, M.

AU - Iwagaki, H.

AU - Tanaka, N.

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AB - Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-α and interferon-γ. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.

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Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells

Abstract

Keywords

ASJC Scopus subject areas

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