Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites

Tomomi Noguchi; Chihiro Shinji; Hisayoshi Kobayashi; Makoto Makishima; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/bpb.28.563

Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites

Tomomi Noguchi, Chihiro Shinji, Hisayoshi Kobayashi, Makoto Makishima, Hiroyuki Miyachi, Yuichi Hashimoto

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Thalidomide (Thal: 1) and its two metabolites, 5-hydroxythalidomide (5-HT: 2) and N-hydroxythalidomide (N-HT: 3), showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation. 5-HT and N-HT showed tubulin polymerization-inhibiting activity, but thalidomide did not.

Original language	English
Pages (from-to)	563-564
Number of pages	2
Journal	Biological and Pharmaceutical Bulletin
Volume	28
Issue number	3
DOIs	https://doi.org/10.1248/bpb.28.563
Publication status	Published - Mar 2005

Keywords

Differentiation
Hydroxythalidomide
Retinoic acid
Thalidomide
Tubulin

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.28.563

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AU - Noguchi, Tomomi

AU - Shinji, Chihiro

AU - Kobayashi, Hisayoshi

AU - Makishima, Makoto

AU - Miyachi, Hiroyuki

AU - Hashimoto, Yuichi

PY - 2005/3

Y1 - 2005/3

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AB - Thalidomide (Thal: 1) and its two metabolites, 5-hydroxythalidomide (5-HT: 2) and N-hydroxythalidomide (N-HT: 3), showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation. 5-HT and N-HT showed tubulin polymerization-inhibiting activity, but thalidomide did not.

KW - Differentiation

KW - Hydroxythalidomide

KW - Retinoic acid

KW - Thalidomide

KW - Tubulin

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Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites

Abstract

Keywords

ASJC Scopus subject areas

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