Enhancement of the affinity of androgen receptor in the adrenal medulla of spontaneously hypertensive rats

Toshio Kumai; Masami Tanaka; Tomonori Tateishi; Minoru Watanabe; Hironori Nakura; Shinichi Kobayashi

doi:10.3109/10641969709083211

Enhancement of the affinity of androgen receptor in the adrenal medulla of spontaneously hypertensive rats

Toshio Kumai, Masami Tanaka, Tomonori Tateishi, Minoru Watanabe, Hironori Nakura, Shinichi Kobayashi

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We investigated the alteration of tyrosine hydroxylase (TH) mRNA expression and androgen receptor in the adrenal medulla of spontaneously hypertensive rats (SHR). The TH mRNA expression in the adrenal medulla of SHR was higher than that of Wistar Kyoto rats (WKY). The testosterone increased the TH mRNA expression of SHR, but not WKY. The affinity of androgen receptor in the adrenal medulla of SHR was higher than that of WKY; however, the number of androgen receptor was not different. These results suggested that the increased binding affinity of the androgen receptor of SHR may be related to TH gene transcription in the adrenal medulla.

Original language	English
Pages (from-to)	1179-1191
Number of pages	13
Journal	Clinical and Experimental Hypertension
Volume	19
Issue number	8
DOIs	https://doi.org/10.3109/10641969709083211
Publication status	Published - Nov 1997
Externally published	Yes

Keywords

Adrenal medulla
Androgen receptor
Inbred SHR
Rats
Tyrosine hydroxylase mRNA

ASJC Scopus subject areas

Internal Medicine
Physiology

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10.3109/10641969709083211

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title = "Enhancement of the affinity of androgen receptor in the adrenal medulla of spontaneously hypertensive rats",

abstract = "We investigated the alteration of tyrosine hydroxylase (TH) mRNA expression and androgen receptor in the adrenal medulla of spontaneously hypertensive rats (SHR). The TH mRNA expression in the adrenal medulla of SHR was higher than that of Wistar Kyoto rats (WKY). The testosterone increased the TH mRNA expression of SHR, but not WKY. The affinity of androgen receptor in the adrenal medulla of SHR was higher than that of WKY; however, the number of androgen receptor was not different. These results suggested that the increased binding affinity of the androgen receptor of SHR may be related to TH gene transcription in the adrenal medulla.",

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T1 - Enhancement of the affinity of androgen receptor in the adrenal medulla of spontaneously hypertensive rats

AU - Kumai, Toshio

AU - Tanaka, Masami

AU - Tateishi, Tomonori

AU - Watanabe, Minoru

AU - Nakura, Hironori

AU - Kobayashi, Shinichi

PY - 1997/11

Y1 - 1997/11

N2 - We investigated the alteration of tyrosine hydroxylase (TH) mRNA expression and androgen receptor in the adrenal medulla of spontaneously hypertensive rats (SHR). The TH mRNA expression in the adrenal medulla of SHR was higher than that of Wistar Kyoto rats (WKY). The testosterone increased the TH mRNA expression of SHR, but not WKY. The affinity of androgen receptor in the adrenal medulla of SHR was higher than that of WKY; however, the number of androgen receptor was not different. These results suggested that the increased binding affinity of the androgen receptor of SHR may be related to TH gene transcription in the adrenal medulla.

AB - We investigated the alteration of tyrosine hydroxylase (TH) mRNA expression and androgen receptor in the adrenal medulla of spontaneously hypertensive rats (SHR). The TH mRNA expression in the adrenal medulla of SHR was higher than that of Wistar Kyoto rats (WKY). The testosterone increased the TH mRNA expression of SHR, but not WKY. The affinity of androgen receptor in the adrenal medulla of SHR was higher than that of WKY; however, the number of androgen receptor was not different. These results suggested that the increased binding affinity of the androgen receptor of SHR may be related to TH gene transcription in the adrenal medulla.

KW - Adrenal medulla

KW - Androgen receptor

KW - Inbred SHR

KW - Rats

KW - Tyrosine hydroxylase mRNA

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Enhancement of the affinity of androgen receptor in the adrenal medulla of spontaneously hypertensive rats

Abstract

Keywords

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