Enzymatic synthesis of β-lactam antibiotics and N-fatty-acylated amino compounds by the acyl-transfer reaction catalyzed by penicillin V acylase from Streptomyces mobaraensis

Mayuko Koreishi; Kazuha Tani; Yuuichi Ise; Hiroyuki Imanaka; Koreyoshi Imamura; Kazuhiro Nakanishi

doi:10.1271/bbb.70052

Enzymatic synthesis of β-lactam antibiotics and N-fatty-acylated amino compounds by the acyl-transfer reaction catalyzed by penicillin V acylase from Streptomyces mobaraensis

Mayuko Koreishi, Kazuha Tani, Yuuichi Ise, Hiroyuki Imanaka, Koreyoshi Imamura, Kazuhiro Nakanishi

School of Engineering

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Penicillin V acylase from Streptomyces mobaraensis (Sm-PVA) showed high acyl-transfer activity in reactions using methyl esters of carboxylic acid (acyl donor) and amino compounds (nucleophile), to produce the corresponding amides. Moreover, Sm-PVA had broad substrate specificity, as indicated by the fact that it catalyzed the efficient synthesis of β-lactam antibiotics, capsaicin derivatives, and N-fatty-acyl-amino acid/N-fatty-acyl-peptide derivatives.

Original language	English
Pages (from-to)	1582-1586
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	71
Issue number	6
DOIs	https://doi.org/10.1271/bbb.70052
Publication status	Published - 2007

Keywords

Acyl transfer reaction
N-fatty-acylated amino compounds
Penicillin V acylase
Streptomyces mobaraensis
β-lactam antibiotics

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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Enzymatic synthesis of β-lactam antibiotics and N-fatty-acylated amino compounds by the acyl-transfer reaction catalyzed by penicillin V acylase from Streptomyces mobaraensis. / Koreishi, Mayuko; Tani, Kazuha; Ise, Yuuichi et al.
In: Bioscience, Biotechnology and Biochemistry, Vol. 71, No. 6, 2007, p. 1582-1586.

Research output: Contribution to journal › Article › peer-review

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AU - Koreishi, Mayuko

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AU - Ise, Yuuichi

AU - Imanaka, Hiroyuki

AU - Imamura, Koreyoshi

AU - Nakanishi, Kazuhiro

PY - 2007

Y1 - 2007

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KW - N-fatty-acylated amino compounds

KW - Penicillin V acylase

KW - Streptomyces mobaraensis

KW - β-lactam antibiotics

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Enzymatic synthesis of β-lactam antibiotics and N-fatty-acylated amino compounds by the acyl-transfer reaction catalyzed by penicillin V acylase from Streptomyces mobaraensis

Abstract

Keywords

ASJC Scopus subject areas

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