Epidemiological correlations between head and neck cancer and Hepatitis B core antibody positivity

Mai Fukushima Komori; Takuji Kimura; Shin Kariya; Tomoo Onoda; Seiko Takeda; Nobuyoshi Mizukawa; Seiji Iida; Yoshihiro Kimata; Kazunori Nishizaki

doi:10.21873/anticanres.14209

Epidemiological correlations between head and neck cancer and Hepatitis B core antibody positivity

Mai Fukushima Komori, Takuji Kimura, Shin Kariya, Tomoo Onoda, Seiko Takeda, Nobuyoshi Mizukawa, Seiji Iida, Yoshihiro Kimata, Kazunori Nishizaki

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background/Aim: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. Patients and Methods: We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008- 2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. Results: Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. Conclusion: HBc antibody positivity and HNC are epidemiologically correlated.

Original language	English
Pages (from-to)	2393-2403
Number of pages	11
Journal	Anticancer research
Volume	40
Issue number	4
DOIs	https://doi.org/10.21873/anticanres.14209
Publication status	Published - Apr 2020

Keywords

HBc antibody
Head and neck cancer
Hepatitis B virus
Multivariate analysis

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.14209

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title = "Epidemiological correlations between head and neck cancer and Hepatitis B core antibody positivity",

abstract = "Background/Aim: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. Patients and Methods: We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008- 2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. Results: Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. Conclusion: HBc antibody positivity and HNC are epidemiologically correlated.",

keywords = "HBc antibody, Head and neck cancer, Hepatitis B virus, Multivariate analysis",

author = "Komori, {Mai Fukushima} and Takuji Kimura and Shin Kariya and Tomoo Onoda and Seiko Takeda and Nobuyoshi Mizukawa and Seiji Iida and Yoshihiro Kimata and Kazunori Nishizaki",

year = "2020",

month = apr,

doi = "10.21873/anticanres.14209",

language = "English",

volume = "40",

pages = "2393--2403",

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T1 - Epidemiological correlations between head and neck cancer and Hepatitis B core antibody positivity

AU - Komori, Mai Fukushima

AU - Kimura, Takuji

AU - Kariya, Shin

AU - Onoda, Tomoo

AU - Takeda, Seiko

AU - Mizukawa, Nobuyoshi

AU - Iida, Seiji

AU - Kimata, Yoshihiro

AU - Nishizaki, Kazunori

PY - 2020/4

Y1 - 2020/4

N2 - Background/Aim: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. Patients and Methods: We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008- 2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. Results: Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. Conclusion: HBc antibody positivity and HNC are epidemiologically correlated.

AB - Background/Aim: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. Patients and Methods: We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008- 2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. Results: Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. Conclusion: HBc antibody positivity and HNC are epidemiologically correlated.

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KW - Head and neck cancer

KW - Hepatitis B virus

KW - Multivariate analysis

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Epidemiological correlations between head and neck cancer and Hepatitis B core antibody positivity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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