Epidemiological study on the relationship between toxin production and psm-mec mutations in MRSA isolates in Thailand

Fumiaki Tabuchi; Aroonlug Lulitanond; Viraphong Lulitanond; Sudaluck Thunyaharn; Chikara Kaito

doi:10.1111/1348-0421.12764

Epidemiological study on the relationship between toxin production and psm-mec mutations in MRSA isolates in Thailand

Fumiaki Tabuchi, Aroonlug Lulitanond, Viraphong Lulitanond, Sudaluck Thunyaharn, Chikara Kaito

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In this present study, we investigated the phenol-soluble modulin (psm-mec) mutations, the staphylococcal cassette chromosome mec (SCCmec) types, and toxin production in 102 methicillin-resistant Staphylococcus aureus (MRSA) isolates from the northeast and central regions of Thailand. The MRSA isolates carrying -7T>C psm-mec in Type II SCCmec (n = 18) and the MRSA isolates carrying no psm-mec in Type IV (n = 8) or Type IX SCCmec (n = 4) had higher hemolytic activity against sheep erythrocytes than MRSA isolates carrying intact psm-mec in Type III SCCmec (n = 34), but MRSA isolates carrying no psm-mec in Type I SCCmec (n = 27) did not.

Original language	English
Pages (from-to)	219-225
Number of pages	7
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	64
Issue number	3
DOIs	https://doi.org/10.1111/1348-0421.12764
Publication status	Published - Mar 1 2020

Keywords

MRSA
SCCmec
psm-mec
toxin
virulence

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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10.1111/1348-0421.12764

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title = "Epidemiological study on the relationship between toxin production and psm-mec mutations in MRSA isolates in Thailand",

abstract = "In this present study, we investigated the phenol-soluble modulin (psm-mec) mutations, the staphylococcal cassette chromosome mec (SCCmec) types, and toxin production in 102 methicillin-resistant Staphylococcus aureus (MRSA) isolates from the northeast and central regions of Thailand. The MRSA isolates carrying -7T>C psm-mec in Type II SCCmec (n = 18) and the MRSA isolates carrying no psm-mec in Type IV (n = 8) or Type IX SCCmec (n = 4) had higher hemolytic activity against sheep erythrocytes than MRSA isolates carrying intact psm-mec in Type III SCCmec (n = 34), but MRSA isolates carrying no psm-mec in Type I SCCmec (n = 27) did not.",

keywords = "MRSA, SCCmec, psm-mec, toxin, virulence",

author = "Fumiaki Tabuchi and Aroonlug Lulitanond and Viraphong Lulitanond and Sudaluck Thunyaharn and Chikara Kaito",

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AU - Tabuchi, Fumiaki

AU - Lulitanond, Aroonlug

AU - Lulitanond, Viraphong

AU - Thunyaharn, Sudaluck

AU - Kaito, Chikara

PY - 2020/3/1

Y1 - 2020/3/1

N2 - In this present study, we investigated the phenol-soluble modulin (psm-mec) mutations, the staphylococcal cassette chromosome mec (SCCmec) types, and toxin production in 102 methicillin-resistant Staphylococcus aureus (MRSA) isolates from the northeast and central regions of Thailand. The MRSA isolates carrying -7T>C psm-mec in Type II SCCmec (n = 18) and the MRSA isolates carrying no psm-mec in Type IV (n = 8) or Type IX SCCmec (n = 4) had higher hemolytic activity against sheep erythrocytes than MRSA isolates carrying intact psm-mec in Type III SCCmec (n = 34), but MRSA isolates carrying no psm-mec in Type I SCCmec (n = 27) did not.

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KW - MRSA

KW - SCCmec

KW - psm-mec

KW - toxin

KW - virulence

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ER -

Epidemiological study on the relationship between toxin production and psm-mec mutations in MRSA isolates in Thailand

Abstract

Keywords

ASJC Scopus subject areas

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